Evidence map›Paper›PMID 27162689›Full record

ArticleJournal of thoracic disease2016

Balanced control of both hyper and hypo-inflammatory phases as a new treatment paradigm in sepsis.

Panagiotis Tsirigotis, Spiros Chondropoulos, Konstantinos Gkirkas, Josef Meletiadis, Ioanna Dimopoulou

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03671746 (Inflammatory Response to Trauma - Does Early Cytokine Modulation Improve Patient Outcome), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03671746 phase1completednot on this mapstarted 2019, after this paper: background citation

Inflammatory Response to Trauma - Does Early Cytokine Modulation Improve Patient Outcome

TypeinterventionalSponsorArun AnejaRan2019 to 2023Enrolled70ConditionsPolytraumaArmsKetorolac, Saline Solution
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. AnACS omega · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Emerging therapeutic targets for sepsis.Expert opinion on therapeutic targets · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Panagiotis Tsirigotis1 Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece ; 2 Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Greece ; 3 Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Spiros Chondropoulos1 Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece ; 2 Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Greece ; 3 Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos Gkirkas1 Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece ; 2 Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Greece ; 3 Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Josef Meletiadis1 Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece ; 2 Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Greece ; 3 Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Ioanna Dimopoulou1 Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece ; 2 Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Greece ; 3 Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune response of the host against invading pathogens is clinically manifested as sepsis. Sepsis is a complicated process characterized by distinct phases that usually occur in a sequential manner. The initial hyper-inflammation helps in elimination of the pathogen, but potentially may lead to excessive tissue injury. Hypo-inflammation helps in restoring immune homeostasis, but may lead to significant immune suppression and death from secondary infections if not appropriately controlled. Immune-modulating intervention in sepsis should be based on a balanced control of both the hyper and the hypo-inflammatory phase.

Indexed as

cytokinesimmune-suppressioninhibitionjanus kinaseSepsis

Identifiers

PMID27162689
PMCPMC4842841
OpenAlexW2336228246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.