Evidence map›Paper›PMID 27162680›Full record

ReviewJournal of thoracic disease2016

Will testosterone replacement therapy become a new treatment of chronic heart failure? A review based on 8 clinical trials.

Weiwei Wang, Ting Jiang, Chunyu Li, Jun Chen, Kejiang Cao, Lian-Wen Qi, Ping Li, Wei Zhu, Baoli Zhu, Yan Chen

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Weiwei Wang1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Ting Jiang1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Chunyu Li1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Jun Chen1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Kejiang Cao1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Lian-Wen Qi1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Ping Li1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Wei Zhu1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Baoli Zhu1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Yan Chen1 Emergency Center, 2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China ; 4 Department of Oncology, the First Affiliated Hospital of Medical University, Nanjing 210029, China ; 5 Institute of Occupational Disease Prevention and Treatment, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210028, China.
Nanjing Medical University · CNJiangsu Province Hospital · CNJiangsu Provincial Center for Disease Control and Prevention · CNChina Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccording to the present evidences suggesting association between low testosterone level and prediction of reduced exercise capacity as well as poor clinical outcome in patients with heart failure, we sought to determine if testosterone replacement therapy (TRT) improves clinical and cardiovascular conditions as well as quality of life status in patients with stable chronic heart failure (CHF).

methodsWe carried out a review based on 8 published clinical trials to determine whether TRT will benefit patients with CHF. Information of exercise capacity, hemodynamic parameters, electrocardiogram indicators, muscle strength, echocardiography guidelines and laboratory indexes were collected to assess clinical outcomes.

resultsWe found that TRT could improve significantly exercise capacity, muscle strength and electrocardiogram indicators but no significant changes in ejection fraction (EF), systolic blood pressure (SBP), diastolic blood pressure (DBP), N-terminal pro-brain natriuretic peptide (NT-proBNP), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6).

conclusionsHigh-quality studies are required to better understand the clinical effects of testosterone.

Indexed as

Heart failure (HF)testosteronetherapy

Identifiers

PMID27162680
PMCPMC4842839
OpenAlexW2336928198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.