ArticleJournal of thoracic disease2016
Down-regulation of miR-452 is associated with poor prognosis in the non-small-cell lung cancer.
Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Downregulation of miRNA-133a and miRNA-452 associated with upregulation of CLNK and LEF1 genes in chronic lymphocytic leukemia: in vitro and in silico insights.Molecular biology reports · 2025Article
- MicroRNA-452: a double-edged sword in multiple human cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Review
- miR-452-5p and miR-215-5p expression levels in colorectal cancer tissues and their relationship with clinicopathological features.Oncology letters · 2020Article
- Circular RNA 0001313 Knockdown Suppresses Non-Small Cell Lung Cancer Cell Proliferation and Invasion via the microRNA-452/HMGB3/ERK/MAPK Axis.International journal of general medicine · 2020Article
- [Characteristics and Influencing Factors of Pathogenic Bacteria in Lung Cancer Chemotherapy Combined with Nosocomial Pulmonary Infection].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2019Article
- miR‑378a‑3p inhibits cellular proliferation and migration in glioblastoma multiforme by targeting tetraspanin 17.Oncology reports · 2019Article
- The relationship between microRNAs and Rab family GTPases in human cancers.Journal of cellular physiology · 2019Review
- MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/β-catenin positive feedback loop.Journal of experimental & clinical cancer research : CR · 2018Article
- Clinical significance of high expression of miR-452-5p in lung squamous cell carcinoma.Oncology letters · 2018Article
- miR-1 inhibits progression of high-risk papillomavirus-associated human cervical cancer by targeting G6PD.Oncotarget · 2016Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-small cell lung cancer (NSCLC) remains the most life-threatening cancer in the world. The aim of the current study was to investigate the value of miR-452 for the prognosis of patients with NSCLC.
methodsReal-time quantitative PCR (qRT-PCR) was used to test the expression level of miR-452 in 161 paired clinical NSCLC tissues and their adjacent tissues. Survival curves were made and the log rank test was used to analyze the survival difference between both groups with higher and lower expression level of miR-452. Univariate and multivariate Cox regression analyses were finally used to determine the independent factors for overall survival (OS) and disease-free survival (DFS) times.
resultsThe miR-452 expressions in tumor samples (n=161) were comparably lower than those in the adjacent tissues. miR-452 expression levels were significantly associated with tumor differentiation grade, tumor size and lymph nodes metastasis. Furthermore, Kaplan-Meier survival curves showed that patients with higher expression of miR-452 was confirmed to have more favorable OS (P=0.004) and DFS (P=0.026). Multivariate survival analysis verified that miR-452 expression level, as well as lymph nodes metastasis, was an independent predictor of both OS and DFS for NSCLC patients.
conclusionsOur study demonstrated that miR-452 functioned as a novel diagnostic biomarker and a promising prognostic predictor for NSCLC patients.
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