ArticleJournal of food science and technology2016
Effect of licorice extract on cell viability, biofilm formation and exotoxin production by Staphylococcus aureus.
Article in Journal of food science and technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Phytochemical Characterization and Anti-Molecules (Basel, Switzerland) · 2025Article
- Synergistic and Long-Lasting Wound Dressings Promote Multidrug-Resistant Staphylococcus Aureus-Infected Wound Healing.International journal of nanomedicine · 2023Article
- Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin.Pharmaceutics · 2022Article
- Mechanism of Synergy between Piceatannol and Ciprofloxacin againstInternational journal of molecular sciences · 2022Article
- Antimicrobial and anti-biofilm activity of thymoquinone against Shigella flexneri.Applied microbiology and biotechnology · 2021Article
- Glycyrrhizin AttenuatesFrontiers in veterinary science · 2021Article
- Rheological Behavior ofFoods (Basel, Switzerland) · 2020Article
- In-vitro evaluation of antimicrobial and insect repellent potential of supercritical-carbon dioxide (SCF-COJournal of food science and technology · 2020Article
- Glabridin Averts Biofilms Formation in Methicillin-ResistantFrontiers in microbiology · 2020Article
- Inhibitory effect of probiotic yeastIranian journal of microbiology · 2019Article
- Treatment of a Woman WithJournal of chiropractic medicine · 2018Article
- Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus is one of the most significant clinical pathogen, as it causes infections to humans and animals. Even though several antibiotics and other treatments have been used to control S. aureus infections and intoxication, bacterium is able to adapt, survive and produces exotoxins. Licorice (Glycyrrhiza glabra L.) has been used traditionally in various medicinal (antimicrobial) preparations, and Glycyrrhizic acid (GA) is the major active constituents present in it. In the present investigation the effect of licorice extract on methicillin susceptible S. aureus (FRI 722) and methicillin resistant S. aureus (ATCC 43300) growth and toxin production was studied. The MIC of licorice extract was found to be 0.25 and 2.5 mg GA ml(-1) against S. aureus FRI 722 and S. aureus ATCC 43300, respectively. Inhibition of biofilm formation was observed even at very low concentration (25 μg GA ml(-1)). Gradual decrease in expression and production of exotoxins such as α and β hemolysins and enterotoxin B was observed with the increasing concentrations of licorice extract, however, suboptimal concentration induced the expression of some of the virulence genes. This study indicated efficacy of licorice extract in controlling growth and pathogenicity of both methicillin susceptible and methicillin resistant S. aureus, however, the mechanisms of survival and toxin production at suboptimal concentration needs further study.
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