ArticleProceedings of the National Academy of Sciences of the United States of America2016
Hedgehog signaling enables nutrition-responsive inhibition of an alternative morph in a polyphenic beetle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed.
- Rewiring of two conserved signalling hubs into one axis underlies convergent female-specific wing regression in insects.Nature ecology & evolution · 2026Article
- Private QTLs and the genetic architecture of hierarchical size traits: from body size to sex-specific plasticity.G3 (Bethesda, Md.) · 2026Article
- Opposing insulin signals underlie the same developmental switch across hemipteran insects.Science advances · 2026Article
- Transcriptomic basis underlying the evolution of female horn plasticity in scarab beetles.Frontiers in zoology · 2026Article
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- Genome evolution and divergence in cis-regulatory architecture is associated with condition-responsive development in horned dung beetles.PLoS genetics · 2024Article
- Gene regulatory networks underlying the development and evolution of plasticity in horned beetles.Current opinion in insect science · 2023Review
- Vertically inherited microbiota and environment-modifying behaviors indirectly shape the exaggeration of secondary sexual traits in the gazelle dung beetle.Ecology and evolution · 2023Article
- A Mediator subunit imparts robustness to a polyphenism decision.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Putting hornets on the genomic map.Scientific reports · 2023Article
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- Comparative metabolomic analysis of polyphenic horn development in the dung beetle Onthophagus taurus.PloS one · 2022Article
- Comparative Proteome Analysis Indicates The Divergence between The Head and Tail Regeneration in Planarian.Cell journal · 2021Article
- Impact of male trait exaggeration on sex-biased gene expression and genome architecture in a water strider.BMC biology · 2021Article
- Wing serial homologues and the diversification of insect outgrowths: insights from the pupae of scarab beetles.Proceedings. Biological sciences · 2021Article
- Polyphenism of a Novel Trait Integrated Rapidly Evolving Genes into Ancestrally Plastic Networks.Molecular biology and evolution · 2021Article
- Computational analyses decipher the primordial folding coding the 3D structure of the beetle horn.Scientific reports · 2021Article
- Divergence in Gut Bacterial Community Structure between Male and Female Stag BeetlesAnimals : an open access journal from MDPI · 2020Article
- Hedgehog signaling is necessary and sufficient to mediate craniofacial plasticity in teleosts.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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2 authors.
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Abstract
The recruitment of modular developmental genetic components into new developmental contexts has been proposed as a central mechanism enabling the origin of novel traits and trait functions without necessitating the origin of novel pathways. Here, we investigate the function of the hedgehog (Hh) signaling pathway, a highly conserved pathway best understood for its role in patterning anterior/posterior (A/P) polarity of diverse traits, in the developmental evolution of beetle horns, an evolutionary novelty, and horn polyphenisms, a highly derived form of environment-responsive trait induction. We show that interactions among pathway members are conserved during development of Onthophagus horned beetles and have retained the ability to regulate A/P polarity in traditional appendages, such as legs. At the same time, the Hh signaling pathway has acquired a novel and highly unusual role in the nutrition-dependent regulation of horn polyphenisms by actively suppressing horn formation in low-nutrition males. Down-regulation of Hh signaling lifts this inhibition and returns a highly derived sigmoid horn body size allometry to its presumed ancestral, linear state. Our results suggest that recruitment of the Hh signaling pathway may have been a key step in the evolution of trait thresholds, such as those involved in horn polyphenisms and the corresponding origin of alternative phenotypes and complex allometries.
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