ArticleProceedings of the National Academy of Sciences of the United States of America2016
Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 37 citations in OpenAlex.
- Spontaneous calcium transients in hair cell stereocilia.Scientific reports · 2025Article
- A force-sensitive adhesion GPCR is required for equilibrioception.Cell research · 2025Article
- Mechanosensitive Ion Channels: The Unending Riddle of Mechanotransduction.Bioelectricity · 2025Review
- Sensory transduction in auditory hair cells-PIEZOs can't touch this.The Journal of general physiology · 2024Article
- Influence of the vestibular system on the neonatal motor behaviors in the gray short-tailed opossum (IBRO neuroscience reports · 2023Article
- Mechanotransduction in mammalian sensory hair cells.Molecular and cellular neurosciences · 2022Review
- PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hair-Bundle Links: Genetics as the Gateway to Function.Cold Spring Harbor perspectives in medicine · 2019Review
- Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex.Cold Spring Harbor perspectives in medicine · 2019Review
- Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance.Cold Spring Harbor perspectives in biology · 2018Review
- Vibration hotspots reveal longitudinal funneling of sound-evoked motion in the mammalian cochlea.Nature communications · 2018Article
- Sensory Hair Cells: An Introduction to Structure and Physiology.Integrative and comparative biology · 2018Review
- Mechanically Gated Ion Channels in Mammalian Hair Cells.Frontiers in cellular neuroscience · 2018Review
- PIEZO2 as the anomalous mechanotransducer channel in auditory hair cells.The Journal of physiology · 2017Review
- In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors.Scientific reports · 2017Article
- CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.Nature communications · 2017Article
- Article
- Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15.PloS one · 2017Article
- Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.Nature neuroscience · 2017Article
- Molecular Identity of the Mechanotransduction Channel in Hair Cells: Not Quiet There Yet.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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4 authors at 2 institutions in 1 country.
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Abstract
Cochlear hair cells normally detect positive deflections of their hair bundles, rotating toward their tallest edge, which opens mechanotransducer (MT) channels by increased tension in interciliary tip links. After tip-link destruction, the normal polarity of MT current is replaced by a mechanically sensitive current evoked by negative bundle deflections. The "reverse-polarity" current was investigated in cochlear hair cells after tip-link destruction with BAPTA, in transmembrane channel-like protein isoforms 1/2 (Tmc1:Tmc2) double mutants, and during perinatal development. This current is a natural adjunct of embryonic development, present in all wild-type hair cells but declining after birth with emergence of the normal-polarity current. Evidence indicated the reverse-polarity current seen developmentally was a manifestation of the same ion channel as that evident under abnormal conditions in Tmc mutants or after tip-link destruction. In all cases, sinusoidal fluid-jet stimuli from different orientations suggested the underlying channels were opened not directly by deflections of the hair bundle but by deformation of the apical plasma membrane. Cell-attached patch recording on the hair-cell apical membrane revealed, after BAPTA treatment or during perinatal development, 90-pS stretch-activated cation channels that could be blocked by Ca(2+) and by FM1-43. High-speed Ca(2+) imaging, using swept-field confocal microscopy, showed the Ca(2+) influx through the reverse-polarity channels was not localized to the hair bundle, but distributed across the apical plasma membrane. These reverse-polarity channels, which we propose to be renamed "unconventional" mechanically sensitive channels, have some properties similar to the normal MT channels, but the relationship between the two types is still not well defined.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.