ArticleNeurorehabilitation and neural repair2016
The Effect of Levodopa on Improvements in Protective Stepping in People With Parkinson's Disease.
Article in Neurorehabilitation and neural repair, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Effects of Oral Levodopa on Balance in People with Idiopathic Parkinson's Disease.Journal of Parkinson's disease · 2023Pooled it
- Dopamine replacement improves motor learning of an upper extremity task in people with Parkinson disease.Behavioural brain research · 2020Trial
- Postural motor learning in Parkinson's disease: The effect of practice on continuous compensatory postural regulation.Gait & posture · 2017Trial
- Body Posture, Postural Stability, and Metabolic Age in Patients with Parkinson's Disease.BioMed research international · 2017Trial
- Excess risk of fracture in incident Parkinson's disease Medicare beneficiaries.Injury epidemiology · 2026Article
- Presence and origin of variability of the pull test and push-and-release test in people with Parkinson's disease.Journal of neurology · 2025Article
- Associating white matter microstructural integrity and improvements in reactive stepping in people with Parkinson's Disease.Brain imaging and behavior · 2024Article
- Postural instability in Parkinson's disease assessed with clinical "pull test" and standardized postural perturbations: effect of medication and body weight support.Journal of neurology · 2023Article
- A Public Data Set With Ground Reaction Forces of Human Balance in Individuals With Parkinson's Disease.Frontiers in neuroscience · 2022Article
- The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson's disease using inertial sensor.NPJ Parkinson's disease · 2021Article
- Comparison of forward and backward postural perturbations in mild-to-moderate Parkinson's disease.Gait & posture · 2021Article
- Sensorimotor Inhibition and Mobility in Genetic Subgroups of Parkinson's Disease.Frontiers in neurology · 2020Article
- Responsiveness of Objective vs. Clinical Balance Domain Outcomes for Exercise Intervention in Parkinson's Disease.Frontiers in neurology · 2020Article
- Motor Learning Deficits in Parkinson's Disease (PD) and Their Effect on Training Response in Gait and Balance: A Narrative Review.Frontiers in neurology · 2019Review
- Wearable Devices in Clinical Trials: Hype and Hypothesis.Clinical pharmacology and therapeutics · 2018Review
- First-trial protective step performance before and after short-term perturbation practice in people with Parkinson's disease.Journal of neurology · 2018Article
- Adaptation of Stability during Perturbed Walking in Parkinson's Disease.Scientific reports · 2017Article
- Long-term effects of exercise and physical therapy in people with Parkinson disease.Nature reviews. Neurology · 2017Review
- Anticipatory Postural Adjustment During Self-Initiated, Cued, and Compensatory Stepping in Healthy Older Adults and Patients With Parkinson Disease.Archives of physical medicine and rehabilitation · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Background The effect of levodopa on postural motor learning in people with Parkinson's disease is poorly understood. In particular, it is unknown whether levodopa affects improvement in protective postural responses after external perturbations such as a slip or trip, a critical aspect of fall prevention. Objective Determine the effect of levodopa on postural motor learning in people with Parkinson's disease. Methods We assessed improvement in protective postural responses in people with Parkinson's disease over short-term (1 day) perturbation training on and off levodopa. We also assessed retention and generalization of improvement. Participants were 22 individuals with Parkinson's disease. The primary outcome was total center of mass (COM) displacement after perturbation. Secondary outcomes assessed first step performance and included margin of stability at first foot contact. Results People with Parkinson's disease improved COM displacement (P = .011) and margin of stability (P = .016) over training. Improvements in these outcomes were more pronounced after training while on levodopa than off levodopa. Levodopa State × Training interactions were not observed for other step performance variables (eg, step latency, length, total number of steps). Improvements were retained for 24 hours, and for margin of stability, retention was more pronounced while on levodopa than off (P = .018). Conclusions Individuals with Parkinson's disease are able to improve protective postural responses through short-term perturbation training, and improvements were more pronounced when on levodopa for some variables. Perturbation training may be more effective if completed while optimally medicated with levodopa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.