Evidence map›Paper›PMID 27162093›Full record

ReviewCurrent opinion in biotechnology2016

Hydrogels for brain repair after stroke: an emerging treatment option.

Lina Ratiba Nih, Stanley Thomas Carmichael, Tatiana Segura

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 119 citations in OpenAlex.

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  8. Brain repair mechanisms after cell therapy for stroke.Brain : a journal of neurology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lina Ratiba NihDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, CA 90095, USA.
Stanley Thomas CarmichaelDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 621 Charles Young Drive, CA 90095, USA.
Tatiana SeguraDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, CA 90095, USA. Electronic address: tsegura@ucla.edu.
University of California, Los Angeles · US

Funding

VEGF Ligand Presentation and Therapeutic AngiogenesisR01NS079691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEGURA, TATIANA · 2012 to 2024
$4.0M
NINDS NIH HHS R01 NS079691
6 · The paper itself

Abstract

Stroke disability is the only major disease without an effective treatment. The substantial clinical burden of stroke in disabled survivors and the lack of a medical therapy that promotes recovery provide an opportunity to explore the use of biomaterials to promote brain repair after stroke. Hydrogels can be injected as a liquid and solidify in situ to form a gelatinous solid with similar mechanical properties to the brain. These biomaterials have been recently explored to generate pro-repair environments within the damaged organ. This review highlights the clinical problem of stroke treatment and discusses recent advances in using in situ forming hydrogels for brain repair.

Indexed as

AnimalsBiocompatible MaterialsBrain DiseasesHumansHydrogelsStrokeWound HealingBiocompatible MaterialsHydrogels

Identifiers

PMID27162093
PMCPMC4975623
OpenAlexW2372550997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.