ArticleCirculation. Arrhythmia and electrophysiology2016
Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation.
Open access · bronzeAbstract read
In one paragraph
Article in Circulation. Arrhythmia and electrophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
3.5field-weighted citation impact, top 9% of its field
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Who cites it
34 citing papers in PubMed, 49 citations in OpenAlex.
- Psychosocial stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse heart.Journal of molecular and cellular cardiology · 2025Article
- Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment.Journal of clinical medicine · 2024Review
- Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling.Scientific reports · 2024Article
- Prostaglandin ICellular and molecular life sciences : CMLS · 2024Article
- The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart.Frontiers in pharmacology · 2024Review
- New-Onset Atrial Fibrillation in the Critically Ill COVID-19 Patients Hospitalized in the Intensive Care Unit.Journal of clinical medicine · 2023Review
- Article
- In Vitro Models for Improved Therapeutic Interventions in Atrial Fibrillation.Journal of personalized medicine · 2023Review
- COVID-19 and atrial fibrillation: Intercepting lines.Frontiers in cardiovascular medicine · 2023Review
- The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study.Scientific reports · 2022Article
- Critical appraisal of technologies to assess electrical activity during atrial fibrillation: a position paper from the European Heart Rhythm Association and European Society of Cardiology Working Group on eCardiology in collaboration with the Heart Rhythm Society, Asia Pacific Heart Rhythm Society, Latin American Heart Rhythm Society and Computing in Cardiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Article
- Epoxylipids and soluble epoxide hydrolase in heart diseases.Biochemical pharmacology · 2022Review
- Recent advances in gene therapy for atrial fibrillation.Journal of cardiovascular electrophysiology · 2021Review
- Atrial fibrillation: the role of hypoxia-inducible factor-1-regulated cytokines.Molecular and cellular biochemistry · 2021Review
- Prestin amplifies cardiac motor functions.Cell reports · 2021Article
- Atrial fibrosis underlying atrial fibrillation (Review).International journal of molecular medicine · 2021Article
- The Critical Roles of Proteostasis and Endoplasmic Reticulum Stress in Atrial Fibrillation.Frontiers in physiology · 2021Review
- Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation.The Journal of general physiology · 2020Article
- Article
- Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy.Stem cells translational medicine · 2020Article
Corrections and comments
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Authors and funding
21 authors at 1 institution in 1 country.
Padmini SirishFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Ning LiFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Valeriy TimofeyevFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Xiao-Dong ZhangFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Lianguo WangFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Jun YangFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Kin Sing Stephen LeeFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Ahmed BettaiebFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Sin Mei MaFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Jeong Han LeeFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Demetria SuFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Victor C LauFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Richard E MyersFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Deborah K LieuFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Javier E LópezFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
J Nilas YoungFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Ebenezer N YamoahFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Fawaz HajFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Crystal M RipplingerFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Bruce D HammockFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.).
Nipavan ChiamvimonvatFrom the Division of Cardiovascular Medicine (P.S., N.L., V.T., X.-D.Z., S.M.M., D.S., V.C.L., R.E.M., D.K.L., J.E.L., N.C.), Department of Pharmacology (L.W., C.M.R.), Department of Entomology and Nematology, Comprehensive Cancer Center (J.Y., K.S.S.L., B.D.H.), Department of Nutrition (A.B., F.H.), and Department of Cardiothoracic Surgery (J.N.Y.), University of California, Davis; Department of Physiology and Cell Biology, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (N.C.). nchiamvimonvat@ucdavis.edu.
University of Nevada, Reno · US
Funding
Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1MUC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5MUC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2MWest Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9MNIEHS Center for Health Effects of AgrochemicalsP30ES005707 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI MATSUMURA, FUMIO NONE · 1992 to 2006
$9.9MFunctional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3MThe Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1MTraining Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1MTranslational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7MPotassium Homeostasis in the Inner EarR01DC007592 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2005 to 2014
$4.5MPROPERTIES AND FUNCTIONS OF CA CHANNELS IN HAIR CELLSR01DC003826 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2000 to 2014
$4.4MHYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0MBLRD VA I01 BX000576CSRD VA I01 CX001490NCATS NIH HHS UL1 TR000002NCRR NIH HHS S10 RR022650NCRR NIH HHS S10 RR033106NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL111600NHLBI NIH HHS R01 HL137228NHLBI NIH HHS T32 HL086350NIDCD NIH HHS R01 DC003826NIDCD NIH HHS R01 DC004215NIDCD NIH HHS R01 DC007592NIDCD NIH HHS R01 DC010386NIDCD NIH HHS R01 DC010917NIDDK NIH HHS K99DK100736NIDDK NIH HHS R01DK090492NIDDK NIH HHS R01 DK095359NIDDK NIH HHS R01DK095359NIDDK NIH HHS U24 DK097154NIEHS NIH HHS K99 ES024806NIEHS NIH HHS P01 ES011269NIEHS NIH HHS P30 ES005707NIEHS NIH HHS P42 ES004699NIEHS NIH HHS P42 ES04699NIEHS NIH HHS R01 ES002710NIH HHS S10 OD010389
Abstract
backgroundAtrial fibrillation represents the most common arrhythmia leading to increased morbidity and mortality, yet, current treatment strategies have proven inadequate. Conventional treatment with antiarrhythmic drugs carries a high risk for proarrhythmias. The soluble epoxide hydrolase enzyme catalyzes the hydrolysis of anti-inflammatory epoxy fatty acids, including epoxyeicosatrienoic acids from arachidonic acid to the corresponding proinflammatory diols. Therefore, the goal of the study is to directly test the hypotheses that inhibition of the soluble epoxide hydrolase enzyme can result in an increase in the levels of epoxyeicosatrienoic acids, leading to the attenuation of atrial structural and electric remodeling and the prevention of atrial fibrillation. METHODS AND
resultsFor the first time, we report findings that inhibition of soluble epoxide hydrolase reduces inflammation, oxidative stress, atrial structural, and electric remodeling. Treatment with soluble epoxide hydrolase inhibitor significantly reduces the activation of key inflammatory signaling molecules, including the transcription factor nuclear factor κ-light-chain-enhancer, mitogen-activated protein kinase, and transforming growth factor-β.
conclusionsThis study provides insights into the underlying molecular mechanisms leading to atrial fibrillation by inflammation and represents a paradigm shift from conventional antiarrhythmic drugs, which block downstream events to a novel upstream therapeutic target by counteracting the inflammatory processes in atrial fibrillation.
Indexed as
AnimalsAnti-Arrhythmia AgentsAnti-Inflammatory AgentsAtrial FibrillationAtrial RemodelingDisease Models, AnimalEnzyme InhibitorsHeart AtriaMaleMiceMice, Inbred C57BLOxidative StressAnti-Arrhythmia AgentsAnti-Inflammatory AgentsEnzyme Inhibitorsanimal modelarrhythmiaatrial fibrillationeicosanoidsinflammation
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