Evidence map›Paper›PMID 27161558›Full record

ReviewReviews of environmental contamination and toxicology

Alkyl Mercury-Induced Toxicity: Multiple Mechanisms of Action.

John F Risher, Pamela Tucker

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reviews of environmental contamination and toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John F RisherDivision of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road (MS F-58), Atlanta, GA, 30333, USA. jrisher@cdc.gov.
Pamela TuckerDivision of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road (MS F-58), Atlanta, GA, 30333, USA.
Agency for Toxic Substances and Disease Registry · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

There are a number of mechanisms by which alkylmercury compounds cause toxic action in the body. Collectively, published studies reveal that there are some similarities between the mechanisms of the toxic action of the mono-alkyl mercury compounds methylmercury (MeHg) and ethylmercury (EtHg). This paper represents a summary of some of the studies regarding these mechanisms of action in order to facilitate the understanding of the many varied effects of alkylmercurials in the human body. The similarities in mechanisms of toxicity for MeHg and EtHg are presented and compared. The difference in manifested toxicity of MeHg and EtHg are likely the result of the differences in exposure, metabolism, and elimination from the body, rather than differences in mechanisms of action between the two.

Indexed as

CalciumEthylmercury CompoundsGlutathioneHumansMethylmercury CompoundsNeurotransmitter AgentsOxidative StressCalciumEthylmercury CompoundsGlutathioneMethylmercury CompoundsNeurotransmitter AgentsArachidonic acidCalcium homeostasisCell cycle/divisionEthylmercuryGlial cellsGlutamateGlutamineGlutathione (GSH)Leukotriene synthesis mechanism of toxicityMembrane permeability/integrityMethylmercuryMitochondriaNeurotransmitter release nitric oxideOxidative stressReactive oxygen speciesReceptor bindingROSThimerosal

Identifiers

PMID27161558
PMCPMC10508330
OpenAlexW2388163770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.