ArticleNeuron2016
Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Anticipatory capture of circulating peptidergic vesicles in a clock neuron.Molecular biology of the cell · 2026Article
- Soma CaCurrent biology : CB · 2026Article
- Desynchronized Somas and Terminals in a Morning Clock Neuron: Presynaptic CabioRxiv : the preprint server for biology · 2025Article
- Article
- Organismal landscape of clock cells and circadian gene expression inbioRxiv : the preprint server for biology · 2023Article
- Polyphasic circadian neural circuits drive differential activities in multiple downstream rhythmic centers.Current biology : CB · 2023Article
- Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling inNational science review · 2022Article
- Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands.PLoS biology · 2022Article
- Regulation of PDF receptor signaling controlling daily locomotor rhythms in Drosophila.PLoS genetics · 2022Article
- The incidence of candidate binding sites for β-arrestin in Drosophila neuropeptide GPCRs.PloS one · 2022Article
- Integration of Circadian Clock Information in theJournal of biological rhythms · 2021Review
- Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior.PLoS biology · 2021Article
- Temporally and spatially partitioned neuropeptide release from individual clock neurons.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Design, Synthesis, and Biological Evaluation of Pyrano[2,3-c]-pyrazole-Based RalA Inhibitors Against Hepatocellular Carcinoma.Frontiers in chemistry · 2021Article
- Ral function in muscle is required for flight maintenance inSmall GTPases · 2020Article
- Model and Non-model Insects in Chronobiology.Frontiers in behavioral neuroscience · 2020Review
- Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain.The European journal of neuroscience · 2020Review
- Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster.PLoS genetics · 2019Article
- Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay.Neuron · 2019Article
- A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies.International journal of molecular sciences · 2019Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The neuropeptide PDF promotes the normal sequencing of circadian behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood. We report daily rhythmicity in responsiveness to PDF in critical pacemakers called small LNvs. There is a daily change in potency, as great as 10-fold higher, around dawn. The rhythm persists in constant darkness and does not require endogenous ligand (PDF) signaling or rhythmic receptor gene transcription. Furthermore, rhythmic responsiveness reflects the properties of the pacemaker cell type, not the receptor. Dopamine responsiveness also cycles, in phase with that of PDF, in the same pacemakers, but does not cycle in large LNv. The activity of RalA GTPase in s-LNv regulates PDF responsiveness and behavioral locomotor rhythms. Additionally, cell-autonomous PDF signaling reversed the circadian behavioral effects of lowered RalA activity. Thus, RalA activity confers high PDF responsiveness, providing a daily gate around the dawn hours to promote functional PDF signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.