ArticleCurrent biology : CB2016
Role for Visual Experience in the Development of Direction-Selective Circuits.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Activity-dependent development of synaptic circuits mediates direction selectivity in an axis-specific manner.Cell reports · 2025Article
- Functionally distinct GABAergic amacrine cell types regulate spatiotemporal encoding in the mouse retina.Nature neuroscience · 2025Article
- Development and organization of the retinal orientation selectivity map.Nature communications · 2024Article
- Differential Expression Analysis Identifies Candidate Synaptogenic Molecules for Wiring Direction-Selective Circuits in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Functional convergence of on-off direction-selective ganglion cells in the visual thalamus.Current biology : CB · 2022Article
- Roles of visually evoked and spontaneous activity in the development of retinal direction selectivity maps.Trends in neurosciences · 2022Review
- Distinct inhibitory pathways control velocity and directional tuning in the mouse retina.Current biology : CB · 2022Article
- The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina.Cell reports · 2022Article
- Development of Functional Properties in the Early Visual System: New Appreciations of the Roles of Lateral Geniculate Nucleus.Current topics in behavioral neurosciences · 2022Review
- Article
- Development of the vertebrate retinal direction-selective circuit.Developmental biology · 2021Review
- Early Visual Motion Experience Improves Retinal Encoding of Motion Directions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit.Cell reports · 2020Article
- Early visual motion experience shapes the gap junction connections among direction selective ganglion cells.PLoS biology · 2020Article
- Stimulus-dependent engagement of neural mechanisms for reliable motion detection in the mouse retina.Journal of neurophysiology · 2018Review
- Neural architecture: from cells to circuits.Journal of neurophysiology · 2018Review
- Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats.Journal of neurophysiology · 2017Article
- Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina.Scientific reports · 2017Article
- Activity-dependent development of visual receptive fields.Current opinion in neurobiology · 2017Review
- Visual Neurons in the Superior Colliculus Innervated by Islet2Frontiers in neural circuits · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Visually guided behavior can depend critically on detecting the direction of object movement. This computation is first performed in the retina where direction is encoded by direction-selective ganglion cells (DSGCs) that respond strongly to an object moving in the preferred direction and weakly to an object moving in the opposite, or null, direction (reviewed in [1]). DSGCs come in multiple types that are classified based on their morphologies, response properties, and targets in the brain. This study focuses on two types-ON and ON-OFF DSGCs. Though animals can sense motion in all directions, the preferred directions of DSGCs in adult retina cluster along distinct directions that we refer to as the cardinal axes. ON DSGCs have three cardinal axes-temporal, ventral, and dorsonasal-while ON-OFF DSGCs have four-nasal, temporal, dorsal, and ventral. How these preferred directions emerge during development is still not understood. Several studies have demonstrated that ON [2] and ON-OFF DSGCs are well tuned at eye-opening, and even a few days prior to eye-opening, in rabbits [3], rats [4], and mice [5-8], suggesting that visual experience is not required to produce direction-selective tuning. However, here we show that at eye-opening the preferred directions of both ON and ON-OFF DSGCs are diffusely distributed and that visual deprivation prevents the preferred directions from clustering along the cardinal axes. Our findings indicate a critical role for visual experience in shaping responses in the retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.