ReviewJournal of neuro-oncology2016
Surgery of insular and paralimbic diffuse low-grade gliomas: technical considerations.
Review in Journal of neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- The specific linear or curved boundaries between WHO grade II-III insular gliomas and the basal ganglia indicate distinct biological features, survival outcomes, and surgical strategies: evidence from 330 cases.NeuroImage. Clinical · 2026Article
- Porto Alegre Line predicts lenticulostriate arteries encasement and extent of resection in insular gliomas. A preliminary study.Frontiers in surgery · 2025Article
- Mini-strokes within Broca-caudate connections during left insular glioma awake surgery cause transient severe naming deficits.Acta neurochirurgica · 2024Article
- Predicting Extent of Resection and Neurological Outcome for Insular Gliomas: An Analysis of Two Available Classifications.Cancers · 2024Article
- Frontal trans opercular approaches to the insula: building the mental picture from procedure-guided anatomical dissection.Surgical and radiologic anatomy : SRA · 2024Article
- The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma.International journal of molecular sciences · 2023Review
- Sexual Dysfunction of Patients with Diffuse Low-Grade Glioma: A Qualitative Review of a Neglected Concern.Cancers · 2022Review
- Anatomical aspects of the insula, opercula and peri-insular white matter for a transcortical approach to insular glioma resection.Neurosurgical review · 2022Article
- Microscope-based augmented reality with diffusion tensor imaging and fluorescein in insular glioma resection.Neurosurgical focus: Video · 2022Article
- Brain connectomics applied to oncological neuroscience: from a traditional surgical strategy focusing on glioma topography to a meta-network approach.Acta neurochirurgica · 2021Review
- Surgical strategy for insular glioma.Journal of neuro-oncology · 2021Review
- Challenging Giant Insular Gliomas With Brain Mapping: Evaluation of Neurosurgical, Neurological, Neuropsychological, and Quality of Life Results in a Large Mono-Institutional Series.Frontiers in oncology · 2021Article
- Awake Surgery for Left Posterior Insular Low-Grade Glioma Through the Parietorolandic Operculum: The Need to Preserve the Functional Connectivity. A Case Series.Frontiers in surgery · 2021Article
- Transcortical approach for insular gliomas: a series of 253 patients.Journal of neuro-oncology · 2020Article
- Neuro-radiological characteristics of adult diffuse grade II and III insular gliomas classified according to WHO 2016.Journal of neuro-oncology · 2019Article
- Surgical management of lower-grade glioma in the spotlight of the 2016 WHO classification system.Journal of neuro-oncology · 2019Article
- Is non-awake surgery for supratentorial adult low-grade glioma treatment still feasible?Neurosurgical review · 2018Review
- Surgery in High-Grade Insular Tumors: Oncological and Seizure Outcomes from 41 Consecutive Patients.Asian journal of neurosurgeryArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Once considered a "no man's land" especially when invaded by a diffuse low grade glioma (DLGG), the insula remains to this day a surgical challenge. Surgery for insular DLGG involves consideration of its hidden location under the potentially eloquent operculae, the proximity to vascular tree and high density of functions not only in the insular cortex but also in the white fiber pathways passing under the insular lobe. The natural history of DLGG and the potential benefits and consequences of the surgical approach also need a close look. In the last decade, a better knowledge of the functional anatomy and connectivity of this region, as well as an improvement in surgical techniques as direct stimulation mapping, combined with an increasing literature showing a favorable impact of maximal resection for DLGG, were deciding factors in the paradigmatic shift from expectative treatment to early surgical management. Here, our goal is to discuss the structural and functional aspects of the insula, the specificities of insular and paralimbic DLGG by emphasizing the technical considerations of surgery in this region, as well as its oncological and functional outcomes. In summary, this new strategy based upon early maximal safe surgical resection showed both oncological benefit and preservation of quality of life-or even an improvement thanks to epilepsy relief.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.