ArticleMayo Clinic proceedings2016
Sex Differences in Cardiorespiratory Fitness and All-Cause Mortality: The Henry Ford ExercIse Testing (FIT) Project.
Article in Mayo Clinic proceedings, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of aerobic exercise on cardiometabolic health in postmenopausal females: A systematic review and meta-analysis of randomized controlled trials.Women's health (London, England)Pooled it
- [Lifestyle: physical activity and training in the prevention and treatment of type 2 diabetes mellitus (Update 2026)].Wiener klinische Wochenschrift · 2026Review
- Determinants of Maximal Oxygen Consumption in Cardiac Rehabilitation Patients: The Role of Sex.Journal of clinical medicine · 2026Article
- The structural and functional aspects of exercise-induced cardiac remodeling and the impact of exercise on cardiovascular outcomes.Annals of medicine · 2025Review
- App-Recorded Daily Step Counts, Sex Differences, and Risk of Cardiovascular Outcomes Among Middle-Aged Population.Journal of the American Heart Association · 2025Article
- Differences Between Health- and Skill-Related Physical Fitness Profiles of Kenyan Children from Urban and Rural Areas: The Kenya-LINX Project.International journal of environmental research and public health · 2025Article
- The Metabolic Signature of Cardiorespiratory Fitness.Scandinavian journal of medicine & science in sports · 2025Article
- Sitting less and moving more: the impact of physical activity on mortality in the population of Spain.BMC public health · 2024Article
- Sex Differences in Effects of Exercise on Physical Function in Aging: A Systematic Review with Meta-Analysis.The world journal of men's health · 2024Article
- Cardiovascular Disease in Chronic Kidney Disease: Implications of Cardiorespiratory Fitness, Race, and Sex.Reviews in cardiovascular medicine · 2024Review
- Sociodemographic Factors Related to Perceived Physical Activity on Chilean Adults after COVID-19 Pandemic.Sports (Basel, Switzerland) · 2024Article
- Exploring the acceptability of three time-matched exercise interventions for increasing fitness in women living with obesity: A mixed-methods evaluation of the EXOFFIT study.Obesity science & practice · 2024Article
- Comparison of time-matched aerobic, resistance or combined exercise training in women living with obesity: The EXOFFIT study.Obesity science & practice · 2024Article
- Association of daily sitting time and leisure-time physical activity with body fat among U.S. adults.Journal of sport and health science · 2024Article
- Sex Differences in Association of Physical Activity With All-Cause and Cardiovascular Mortality.Journal of the American College of Cardiology · 2024Article
- Cardiorespiratory Fitness Benefits of Long-Term Maintenance-Phase Cardiac Rehabilitation in Males and Females: A Retrospective Cohort Study.Physiotherapy Canada. Physiotherapie Canada · 2024Article
- Leisure-time physical activity, daily sitting time, and mortality among US skin cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Mental Health in Adults With ADHD: Examining the Relationship With Cardiorespiratory Fitness.Journal of attention disorders · 2023Article
- [Lifestyle: physical activity and training as prevention and therapy of type 2 diabetes mellitus (Update 2023)].Wiener klinische Wochenschrift · 2023Article
- External validation of VO2max prediction models based on recreational and elite endurance athletes.PloS one · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectiveTo determine whether sex modifies the relationship between fitness and mortality. PATIENTS AND
methodsWe included 57,284 patients without coronary artery disease or heart failure who completed a routine treadmill exercise test between 1991 and 2009. We determined metabolic equivalent tasks (METs) and linked patient records with mortality data via the Social Security Death Index. Multivariable Cox regression was used to determine the association between sex, fitness, and all-cause mortality.
resultsThere were 29,470 men (51.4%) and 27,814 women (48.6%) with mean ages of 53 and 54 years, respectively. Overall, men achieved 1.7 METs higher than women (P<.001). During median follow-up of 10 years, there were 6402 deaths. The mortality rate for men in each MET group was similar to that for women, who achieved an average of 2.6 METs lower (P=.004). Fitness was inversely associated with mortality in both men (hazard ratio [HR], 0.84 per 1 MET; 95% CI, 0.83-0.85) and women (HR, 0.83 per 1 MET; 95% CI, 0.81-0.84). This relationship did not plateau at high or low MET values.
conclusionAlthough men demonstrated 1.7 METs higher than women, their survival was equivalent to that of women demonstrating 2.6 METs lower. Furthermore, higher MET values were associated with lower mortality for both men and women across the range of MET values. These findings are useful for tailoring prognostic information and lifestyle guidance to men and women undergoing stress testing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.