SynthesisNeurocritical care2016
Intracerebral Hemorrhage Location and Functional Outcomes of Patients: A Systematic Literature Review and Meta-Analysis.
Synthesis in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Neuroendoscopy Versus External Ventricular Drainage for Thalamic Hemorrhagic Stroke: A Systematic Review and Bayesian Meta-Analysis.Brain and behavior · 2026Pooled it
- Efficacy of minimally invasive surgery versus conventional procedures for thalamic stroke hemorrhage: systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Guidelines for Neuroprognostication in Critically Ill Adults with Intracerebral Hemorrhage.Neurocritical care · 2024Guideline
- Methodological quality of multivariate prognostic models for intracranial haemorrhages in intensive care units: a systematic review.BMJ open · 2021Pooled it
- Intracerebral haemorrhage laterality and associations with mood and pain: a MISTIE III substudy.Stroke and vascular neurology · 2025Trial
- The Prognostic Roles of Perihematomal Edema and Ventricular Size in Patients with Intracerebral Hemorrhage.Neurocritical care · 2022Trial
- Association of Location-Specific Perihematomal Edema with Clinical Outcomes in Deep Intracerebral Hemorrhage.Neurocritical care · 2026Article
- Analysis of influencing factors in patients with hypertensive intracerebral hemorrhage in the basal ganglia region treated with stereotactic surgery.Neurosurgical review · 2026Article
- Comparing manual and automated methods for extracting perihematomal features in predicting hemorrhage expansion in deep intracerebral hemorrhage.Scientific reports · 2026Article
- White Matter Structural Biomarkers Derived from Diffusion Tensor Imaging to Estimate Upper-Extremity Motor Function in Stroke Using Machine Learning.Brain topography · 2026Article
- Optimal hematoma volume cutoffs and efficacy of minimally invasive surgery for thalamic hemorrhage: a propensity score-matched analysis.BMC neurology · 2026Observational
- Effects of Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs on Acute Intracerebral Hemorrhage.Annals of clinical and translational neurology · 2025Article
- Association of the ICH Score With Withdrawal of Life-Sustaining Treatment Over a 10-Year Period.Annals of clinical and translational neurology · 2025Article
- Effect of admission blood glucose on early mortality in patients with pontine hemorrhage.Scientific reports · 2025Article
- Machine learning-based prediction of 90-day prognosis and in-hospital mortality in hemorrhagic stroke patients.Scientific reports · 2025Article
- Article
- Incidence But Not Severity of Intracerebral Hemorrhage Shows a Strong Pattern of Seasonal Variation.Journal of the American Heart Association · 2025Article
- Location and Timing of Recurrent, Nontraumatic Intracerebral Hemorrhage.JAMA neurology · 2025Article
- Usefulness of Serum NOX4 as a Potential Biomarker to Predict Early Neurological Deterioration and Poor Outcome of Spontaneous Intracerebral Hemorrhage: A Prospective Observational Study.Neuropsychiatric disease and treatment · 2025Article
- Serum P2X7 as a prognostic biomarker in acute supratentorial intracerebral hemorrhage: a two-center observational study.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
background and purposeIntracerebral hemorrhage (ICH) has the highest mortality rate among all strokes. While ICH location, lobar versus non-lobar, has been established as a predictor of mortality, less is known regarding the relationship between more specific ICH locations and functional outcome. This review summarizes current work studying how ICH location affects outcome, with an emphasis on how studies designate regions of interest.
methodsA systematic search of the OVID database for relevant studies was conducted during August 2015. Studies containing an analysis of functional outcome by ICH location or laterality were included. As permitted, the effect size of individual studies was standardized within a meta-analysis.
resultsThirty-seven studies met the inclusion criteria, the majority of which followed outcome at 3 months. Most studies found better outcomes on the Modified Rankin Scale (mRS) or Glasgow Outcome Score (GOS) with lobar compared to deep ICHs. While most aggregated deep structures for analysis, some studies found poorer outcomes for thalamic ICH in particular. Over half of the studies did not have specific methodological considerations for location designations, including blinding or validation.
conclusionsMultiple studies have examined motor-centric outcomes, with few studies examining quality of life (QoL) or cognition. Better functional outcomes have been suggested for lobar versus non-lobar ICH; few studies attempted finer topographic comparisons. This study highlights the need for improved reporting in ICH outcomes research, including a detailed description of hemorrhage location, reporting of the full range of functional outcome scales, and inclusion of cognitive and QoL outcomes.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.