ArticleBreast cancer research : BCR2016
Tumor characterization and treatment monitoring of postsurgical human breast specimens using harmonic motion imaging (HMI).
Article in Breast cancer research : BCR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05219695 (Medical Imaging and Focused Ultrasound Treatment for Breast Tumors Using Harmonic Motion Imaging), which is not on this map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Medical Imaging and Focused Ultrasound Treatment for Breast Tumors Using Harmonic Motion Imaging (HMI)
Who cites it
18 citing papers in PubMed.
- Hydroxyapatite-mineralized metal-organic frameworks as sonosensitizer modulate tumor microenvironment to potentiate high-intensity focused ultrasound therapy.Materials today. Bio · 2026Article
- Hypoxia-specific metal-organic frameworks combined with lactate immunometabolism regulation augment anti-tumor immunity of HIFU.Materials today. Bio · 2026Article
- A Multimodal Ultrasound-Driven Approach for Automated Tumor Assessment With B-Mode and Multi-Frequency Harmonic Motion Images.IEEE transactions on bio-medical engineering · 2026Article
- Therapeutic Ultrasound for Multimodal Cancer Treatment: A Spotlight on Breast Cancer.Annual review of biomedical engineering · 2025Review
- Amplitude-Modulation Frequency Optimization for Enhancing Harmonic Motion Imaging Performance of Breast Tumors in the Clinic.Ultrasound in medicine & biology · 2025Article
- Harmonic Motion Imaging-Guided Focused Ultrasound Ablation: Comparison of Three Focused Ultrasound Interference Filtering Methods.Ultrasound in medicine & biology · 2024Article
- Optimization of the Tracking Beam Sequence in Harmonic Motion Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- The impact of amplitude modulation frequency in harmonic motion imaging on inclusion characterization.Ultrasound in medicine & biology · 2023Article
- An Efficient and Multi-Focal Focused Ultrasound Technique for Harmonic Motion Imaging.IEEE transactions on bio-medical engineering · 2023Article
- Feasibility of Harmonic Motion Imaging Using a Single Transducer: In Vivo Imaging of Breast Cancer in a Mouse Model and Human Subjects.IEEE transactions on medical imaging · 2021Article
- An analytical model of full-field displacement and strain induced by amplitude-modulated focused ultrasound in harmonic motion imaging.Physics in medicine and biology · 2021Article
- Displacement Imaging During Focused Ultrasound Median Nerve Modulation: A Preliminary Study in Human Pain Sensation Mitigation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Synchronous temperature variation monitoring during ultrasound imaging and/or treatment pulse application: a phantom study.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2021Article
- Harmonic motion imaging of human breast masses: an in vivo clinical feasibility.Scientific reports · 2020Article
- Harmonic Motion Imaging of Pancreatic Tumor Stiffness Indicates Disease State and Treatment Response.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Acoustic Radiation Force Based Ultrasound Elasticity Imaging for Biomedical Applications.Sensors (Basel, Switzerland) · 2018Review
- Focused Ultrasound Steering for Harmonic Motion Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018Article
- Fast lesion mapping during HIFU treatment using harmonic motion imaging guided focused ultrasound (HMIgFUS) in vitro and in vivo.Physics in medicine and biology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundHigh-intensity focused ultrasound (HIFU) is a noninvasive technique used in the treatment of early-stage breast cancer and benign tumors. To facilitate its translation to the clinic, there is a need for a simple, cost-effective device that can reliably monitor HIFU treatment. We have developed harmonic motion imaging (HMI), which can be used seamlessly in conjunction with HIFU for tumor ablation monitoring, namely harmonic motion imaging for focused ultrasound (HMIFU). The overall objective of this study was to develop an all ultrasound-based system for real-time imaging and ablation monitoring in the human breast in vivo.
methodsHMI was performed in 36 specimens (19 normal, 15 invasive ductal carcinomas, and 2 fibroadenomas) immediately after surgical removal. The specimens were securely embedded in a tissue-mimicking agar gel matrix and submerged in degassed phosphate-buffered saline to mimic in vivo environment. The HMI setup consisted of a HIFU transducer confocally aligned with an imaging transducer to induce an oscillatory radiation force and estimate the resulting displacement.
results3D HMI displacement maps were reconstructed to represent the relative tissue stiffness in 3D. The average peak-to-peak displacement was found to be significantly different (p = 0.003) between normal breast tissue and invasive ductal carcinoma. There were also significant differences before and after HMIFU ablation in both the normal (53.84 % decrease) and invasive ductal carcinoma (44.69 % decrease) specimens.
conclusionsHMI can be used to map and differentiate relative stiffness in postsurgical normal and pathological breast tissues. HMIFU can also successfully monitor thermal ablations in normal and pathological human breast specimens. This HMI technique may lead to a new clinical tool for breast tumor imaging and HIFU treatment monitoring.
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Registered trials
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