ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2016
Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Cancer Risks in Solid Organ Transplant Recipients: Results from a Comprehensive Analysis of 72 Cohort Studies.Oncoimmunology · 2020Pooled it
- Pooled it
- Modeling Complex Developmental Disease: The Case of Polycystic Kidney Disease.Journal of developmental biology · 2026Review
- Population-level cancer trends among solid organ transplant recipients in the United States during 1995-2021.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Unveiling the silent burden: high prevalence of occult nephropathies in radical nephrectomy specimens.Clinical kidney journal · 2026Article
- Review
- Solid masses arising in transplanted kidneys.Abdominal radiology (New York) · 2026Review
- Early-Onset Bilateral Clear Cell Renal Cell Carcinoma in a Pediatric Renal Transplant Recipient: A Rare Case Report.Case reports in urology · 2026Article
- Association Between Renal Cell Cancer and Chronic Kidney Disease: An Update on a Never-Healing Wound.Biomedicines · 2025Review
- De Novo Renal Cell Carcinoma in Kidney Transplant Recipients: Incidence, Outcomes, and Therapeutic Challenges.Cancers · 2025Article
- Anti-nuclear cytoplasmic antibody-associated vasculitis and kidney cancer: A mini review.World journal of nephrology · 2025Review
- Surgical Management of Renal Cell Carcinoma in Transplanted Kidneys-A Narrative Review.Cancers · 2025Review
- Renal cell carcinoma and upper tract urothelial carcinoma in kidney transplant recipients.Journal of medicine and life · 2025Article
- Renal cell carcinoma of the native kidney in renal transplant recipients: case report and literature review.Frontiers in oncology · 2025Article
- Clinical features and mutational frequency of renal cell carcinoma from patients undergoing kidney transplant evaluation.Frontiers in oncology · 2025Article
- Calcium Channel Blocker Versus Renin-Angiotensin System Inhibitor in Risk of Kidney Cancer Among Patients With Hypertension: A Propensity Score-Matched Cohort Study.Cancer medicine · 2024Article
- Edible mushroom (Anatomy & cell biology · 2024Article
- [Urogenital tumors following kidney transplantation-monocentric analysis of incidences and overview of urological preventive measures].Urologie (Heidelberg, Germany) · 2024Article
- The Link between Autosomal Dominant Polycystic Kidney Disease and Chromosomal Instability: Exploring the Relationship.International journal of molecular sciences · 2024Article
- Monogenic Kidney Diseases in Kidney Transplantation.Kidney international reports · 2024Review
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10 authors at 6 institutions in 1 country.
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Abstract
Renal cell carcinoma (RCC) is a common malignancy following kidney transplantation. We describe RCC risk and examine RCC risk factors among US kidney recipients (1987-2010). The Transplant Cancer Match Study links the US transplant registry with 15 cancer registries. Standardized incidence ratios (SIRs) were used to compare RCC risk (overall and for clear cell [ccRCC] and papillary subtypes) to the general population. Associations with risk factors were assessed using Cox models. We identified 683 RCCs among 116 208 kidney recipients. RCC risk was substantially elevated compared with the general population (SIR 5.68, 95% confidence interval 5.27-6.13), especially for papillary RCC (SIR 13.3 versus 3.98 for ccRCC). Among kidney recipients, RCC risk was significantly elevated for blacks compared to whites (hazard ratio [HR] 1.50) and lower in females than males (HR 0.56). RCC risk increased with prolonged dialysis preceding transplantation (p-trend < 0.0001). Risk was variably associated for RCC subtypes with some medical conditions that were indications for transplantation: ccRCC risk was reduced with polycystic kidney disease (HR 0.54), and papillary RCC was increased with hypertensive nephrosclerosis (HR 2.02) and vascular diseases (HR 1.86). In conclusion, kidney recipients experience substantially elevated risk of RCC, especially for papillary RCC, and multiple factors contribute to these cancers.
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