ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Antimicrobial defence and persistent infection in insects revisited.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Pharmacokinetics determine persister formation inJAC-antimicrobial resistance · 2026Article
- Edible Insects as Future Proteins: Nutritional Value, Functional Properties, Bioactivities, and Safety Perspectives.Nutrients · 2025Review
- Impact ofInsects · 2025Article
- A Trade-Off Between Antimicrobial Peptide Resistance and Sensitivity to Host Immune Effectors inEvolutionary applications · 2025Article
- Infection risk by oral contamination does not induce immune priming in the mealworm beetle (Frontiers in immunology · 2024Article
- The effect of combined knockdowns of Attacins on survival and bacterial load inFrontiers in immunology · 2023Article
- Transcriptome Analysis Reveals Early Hemocyte Responses upon In Vivo Stimulation with LPS in the Stick InsectInsects · 2022Article
- Polymeric Coatings and Antimicrobial Peptides as Efficient Systems for Treating Implantable Medical Devices Associated-Infections.Polymers · 2022Review
- Evaluation of antibacterial activity induced bySaudi journal of biological sciences · 2022Article
- Multiple mosquito AMPs are needed to potentiate their antifungal effect against entomopathogenic fungi.Frontiers in microbiology · 2022Article
- Host Resistance to Bacterial Infection Varies Over Time, but Is Not Affected by a Previous Exposure to the Same Pathogen.Frontiers in physiology · 2022Article
- Diverse Host Immune Responses of Different Geographical Populations of the Coconut Rhinoceros Beetle to Oryctes Rhinoceros Nudivirus (OrNV) Infection.Microbiology spectrum · 2021Article
- Inoculum effect of antimicrobial peptides.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Bacteria primed by antimicrobial peptides develop tolerance and persist.PLoS pathogens · 2021Article
- Attacins: A Promising Class of Insect Antimicrobial Peptides.Antibiotics (Basel, Switzerland) · 2021Review
- Deciphering the molecular mechanisms of mother-to-egg immune protection in the mealworm beetle Tenebrio molitor.PLoS pathogens · 2020Article
- Enzymatic, antimicrobial, and leishmanicidal bioactivity of gram-negative bacteria strains from the midgut ofBiotechnology reports (Amsterdam, Netherlands) · 2019Article
- Immune Defenses of a Beneficial Pest: The Mealworm Beetle,Frontiers in physiology · 2019Review
- Article
- The Enhanced Immune Protection in Chinese Mitten CrabFrontiers in immunology · 2019Article
Corrections and comments
- Erratum issuedCorrection to: 'Antimicrobial defence and persistent infection in insects revisited'.2016 · Rodríguez-Rojas, Alex [corrected to Rodríguez-Rojas, Alexandro]
Authors and funding
7 authors.
Funding
Abstract
Insects show long-lasting antimicrobial immune responses that follow the initial fast-acting cellular processes. These immune responses are discussed to provide a form of phrophylaxis and/or to serve as a safety measure against persisting infections. The duration and components of such long-lasting responses have rarely been studied in detail, a necessary prerequisite to understand their adaptive value. Here, we present a 21 day proteomic time course of the mealworm beetle Tenebrio molitor immune-challenged with heat-killed Staphylococcus aureus The most upregulated peptides are antimicrobial peptides (AMPs), many of which are still highly abundant 21 days after infection. The identified AMPs included toll and imd-mediated AMPs, a significant number of which have no known function against S. aureus or other Gram-positive bacteria. The proteome reflects the selective arena for bacterial infections. The results also corroborate the notion of synergistic interactions in vivo that are difficult to model in vitroThis article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.