ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Friend, foe or food? Recognition and the role of antimicrobial peptides in gut immunity and Drosophila-microbe interactions.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
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- Microbial Community Dynamics in Natural Drosophila melanogaster Populations Across Seasons.Environmental microbiology · 2025Article
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- Identification of anFrontiers in cellular and infection microbiology · 2025Article
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- Chitosan oligosaccharide improves intestinal homeostasis to achieve the protection for the epithelial barrier of femaleMicrobiology spectrum · 2024Article
- Cellular and molecular organization of the Drosophila foregut.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- High-fat diets induce inflammatory IMD/NFκB signaling via gut microbiota remodeling inFrontiers in cellular and infection microbiology · 2024Article
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- Drosophila caspases as guardians of host-microbe interactions.Cell death and differentiation · 2023Review
- RNA-Sequencing of Heterorhabditis nematodes to identify factors involved in symbiosis with Photorhabdus bacteria.BMC genomics · 2022Article
- A Functional Analysis of the Purine Salvage Pathway in Acetobacter fabarum.Journal of bacteriology · 2022Article
- Aspirin Positively Contributes toAging and disease · 2021Article
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- Theaflavin-regulated Imd condensates controliScience · 2021Article
- Critical Roles of Spätzle5 in Antimicrobial Peptide Production AgainstFrontiers in immunology · 2021Article
- Evolution of animal immunity in the light of beneficial symbioses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Microbiomes as modulators of Drosophila melanogaster homeostasis and disease.Current opinion in insect science · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila melanogaster lives, breeds and feeds on fermenting fruit, an environment that supports a high density, and often a diversity, of microorganisms. This association with such dense microbe-rich environments has been proposed as a reason that D. melanogaster evolved a diverse and potent antimicrobial peptide (AMP) response to microorganisms, especially to combat potential pathogens that might occupy this niche. Yet, like most animals, D. melanogaster also lives in close association with the beneficial microbes that comprise its microbiota, or microbiome, and recent studies have shown that antimicrobial peptides (AMPs) of the epithelial immune response play an important role in dictating these interactions and controlling the host response to gut microbiota. Moreover, D. melanogaster also eats microbes for food, consuming fermentative microbes of decaying plant material and their by-products as both larvae and adults. The processes of nutrient acquisition and host defence are remarkably similar and use shared functions for microbe detection and response, an observation that has led to the proposal that the digestive and immune systems have a common evolutionary origin. In this manner, D. melanogaster provides a powerful model to understand how, and whether, hosts differentiate between the microbes they encounter across this spectrum of associations.This article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.