ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
The potential for adaptive maintenance of diversity in insect antimicrobial peptides.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Artificial intelligence catalyzes antimicrobial peptide design.Synthetic and systems biotechnology · 2027Review
- Predictors of Protein Evolution in the drosophilid Immune System.Genome biology and evolution · 2026Article
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- Dual Disruption of the Immune Cytokine Spätzle Facilitates Fungal Infection of Diverse Insect Hosts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
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- Identification of Multifunctional Putative Bioactive Peptides in the Insect Model Red Palm Weevil (Biomolecules · 2024Article
- Identification of Multifunctional Putative Bioactive Peptides in the Insect Model Red Palm Weevil (Biomolecules · 2024Article
- The role of uncertainty and negative feedback loops in the evolution of induced immune defenses.G3 (Bethesda, Md.) · 2024Article
- A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation.Signal transduction and targeted therapy · 2024Review
- A single amino acid polymorphism in natural Metchnikowin alleles of Drosophila results in systemic immunity and life history tradeoffs.PLoS genetics · 2024Article
- Article
- Alternate Antimicrobial Therapies and Their Companion Tests.Diagnostics (Basel, Switzerland) · 2023Review
- Signatures of Adaptation, Constraints, and Potential Redundancy in the Canonical Immune Genes of a Key Pollinator.Genome biology and evolution · 2023Article
- Article
- Article
- Why do insects evolve immune priming? A search for crossroads.Developmental and comparative immunology · 2022Review
- Evolving and assembling to pierce through: Evolutionary and structural aspects of antimicrobial peptides.Computational and structural biotechnology journal · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Genes involved in immune defence are among the fastest evolving in the genomes of many species. Interestingly, however, genes encoding antimicrobial peptides (AMPs) have shown little evidence for adaptive divergence in arthropods, despite the centrality of these peptides in direct killing of microbial pathogens. This observation, coupled with a failure to detect phenotypic consequence of genetic variation in AMPs, has led to the hypothesis that individual AMPs make minor contributions to overall immune defence and that AMPs instead act as a collective cocktail. Recent data, however, have suggested an alternative explanation for the apparent lack of adaptive divergence in AMP genes. Molecular evolutionary and phenotypic data have begun to suggest that variant AMP alleles may be maintained through balancing selection in invertebrates, a pattern similar to that observed in several vertebrate AMPs. Signatures of balancing selection include high rates of non-synonymous polymorphism, trans-species amino acid polymorphisms, and convergence of amino acid states across the phylogeny. In this review, we revisit published literature on insect AMP genes and analyse newly available population genomic datasets in Drosophila, finding enrichment for patterns consistent with adaptive maintenance of polymorphism.This article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.
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