ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Diversity, evolution and medical applications of insect antimicrobial peptides.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
110 citing papers in PubMed.
- Oral Exposure toInsects · 2026Article
- Is the developmental stage important for the plasticity of transgenerational immune priming?Biology open · 2026Article
- Review
- Exploring the Antimicrobial Potential of a Peptide Against Mixed Biofilm of Staphylococcus aureus and Candida albicans.Probiotics and antimicrobial proteins · 2026Article
- Aquatic BPI/LBPs: A Promising Antimicrobial Peptide Resource for Disease Control in Aquaculture.Current protein & peptide science · 2026Review
- Novel antimicrobial peptides and peptide-microbiome crosstalk in Appalachian salamander skin.NPJ biofilms and microbiomes · 2025Article
- Edible Insects as Future Proteins: Nutritional Value, Functional Properties, Bioactivities, and Safety Perspectives.Nutrients · 2025Review
- Identification and antibacterial activity of a novel antimicrobial peptide attacin from Conogethes punctiferalis.Archives of microbiology · 2025Article
- Serine protease inhibitor dipetalogastin-like from Galleria mellonella is involved in insect immunity.Scientific reports · 2025Article
- Characterization of avian β-defensin genes in Galliformes reveals widespread evolutionary diversification and distinct evolutionary relationships with infection risk.BMC genomics · 2025Article
- Biological Activity of Peptide Fraction Derived fromInternational journal of molecular sciences · 2025Article
- A Trade-Off Between Antimicrobial Peptide Resistance and Sensitivity to Host Immune Effectors inEvolutionary applications · 2025Article
- Recent advances in host models in studying virulence factors and pathogenesis ofFrontiers in cellular and infection microbiology · 2025Review
- Article
- Effect of Bioactive Peptides on Gut Microbiota and Their Relations to Human Health.Foods (Basel, Switzerland) · 2024Review
- Peptides with Antimicrobial Activity in the Saliva of the Malaria VectorInternational journal of molecular sciences · 2024Article
- When the microbiome shapes the host: immune evolution implications for infectious disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Insect Antimicrobial Peptides as Guardians of Immunity and Beyond: A Review.International journal of molecular sciences · 2024Review
- Article
- Diversity and Mechanisms of Action of Plant, Animal, and Human Antimicrobial Peptides.Antibiotics (Basel, Switzerland) · 2024Review
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides (AMPs) are short proteins with antimicrobial activity. A large portion of known AMPs originate from insects, and the number and diversity of these molecules in different species varies considerably. Insect AMPs represent a potential source of alternative antibiotics to address the limitation of current antibiotics, which has been caused by the emergence and spread of multidrug-resistant pathogens. To get more insight into AMPs, we investigated the diversity and evolution of insect AMPs by mapping their phylogenetic distribution, allowing us to predict the evolutionary origins of selected AMP families and to identify evolutionarily conserved and taxon-specific families. Furthermore, we highlight the use of the nematode Caenorhabditis elegans as a whole-animal model in high-throughput screening methods to identify AMPs with efficacy against human pathogens, including Acinetobacter baumanii and methicillin-resistant Staphylococcus aureus We also discuss the potential medical applications of AMPs, including their use as alternatives for conventional antibiotics in ectopic therapies, their combined use with antibiotics to restore the susceptibility of multidrug-resistant pathogens, and their use as templates for the rational design of peptidomimetic drugs that overcome the disadvantages of therapeutic peptides.The article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.