ArticleBMC pulmonary medicine2016
Assessing health-related quality of life in COPD: comparing generic and disease-specific instruments with focus on comorbidities.
Article in BMC pulmonary medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 65 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis and Utilisation of Health Care Resources in Patients With COPD
Efficacy of Education Programs in Patients With Chronic Airway Diseases
Who cites it
65 citing papers in PubMed, 5 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- The impact of fibroid treatments on quality of life and mental health: a systematic review.Fertility and sterility · 2024Pooled it
- Measurement properties of preference-based measures for economic evaluation in COPD: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Pooled it
- A systematic review and meta-analysis of Liuzijue in stable patients with chronic obstructive pulmonary disease.BMC complementary medicine and therapies · 2020Pooled it
- Economic Burden of Chronic Obstructive Pulmonary Disease (COPD): A Systematic Literature Review.International journal of chronic obstructive pulmonary disease · 2020Pooled it
- A Systematic Literature Review of the Humanistic Burden of COPD.International journal of chronic obstructive pulmonary diseasePooled it
- Trial
- How does the EQ-5D-5L perform in asthma patients compared with an asthma-specific quality of life questionnaire?BMC pulmonary medicine · 2020Trial
- Measurement properties of a patient-reported outcome scale for peptic ulcer: a validation study using classical test theory and generalizability theory.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Health outcomes in older adults with COPD: the role of clinical and psychosocial factors in post-acute geriatric rehabilitation.NPJ primary care respiratory medicine · 2026Article
- A longitudinal study on the correlation between symptom clusters and disease-specific health status in older adults with chronic obstructive pulmonary disease during pulmonary rehabilitation.Frontiers in public health · 2026Article
- Cost-effectiveness modeling of mortality risk reduction comparing two fixed-dose combination triple therapies in moderate-to-very severe chronic obstructive pulmonary disease.Journal of comparative effectiveness research · 2026Article
- Changes in quality of life and work status after surgical management of meralgia paresthetica- an observational cohort study.Brain & spine · 2026Article
- Double burdened yet resilient: quality of life of caregivers of people with X-linked hypophosphatemia.JBMR plus · 2025Article
- Diabetes mellitus, cardiovascular and chronic respiratory diseases in Germany and Europe - results of the European Health Interview Survey (EHIS 3, 2018 - 2020).Journal of health monitoring · 2024Article
- Health-related quality of life predicts prognosis in individuals with COPD hospitalized with community-acquired pneumonia - a prospective cohort study.Scientific reports · 2024Article
- Respiratory Pathogens at Exacerbation in Chronic Bronchitis With Airway Bacterial Colonisation: A Cohort Study.The clinical respiratory journal · 2024Article
- Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.ERJ open research · 2024Article
- Translation and cross-cultural adaptation of the Kidney Transplant Questionnaire 25 to Greek.World journal of transplantation · 2024Article
- Impact of comorbidities in COPD clinical control criteria. The CLAVE study.BMC pulmonary medicine · 2024Article
- Does uptake of specialty care affect HRQoL development in COPD patients beneficially? A difference-in-difference analysis linking claims and survey data.The European journal of health economics : HEPAC : health economics in prevention and care · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic Obstructive Pulmonary Disease (COPD) influences different aspects of patient's health-related quality of life (HRQL). While disease-specific HRQL instruments focus on symptoms and functional impairments, generic instruments cover a broader view on health. This study compares the generic EQ-5D-3 L and two disease-specific questionnaires (St.-George's Respiratory Questionnaire (SGRQ-C), COPD Assessment Test (CAT)) in a comprehensive spectrum of COPD disease grades with particular attention on comorbidities and assesses the discriminative abilities of these instruments.
methodsUsing data from the baseline visit of the German COPD cohort COSYCONET, mean HRQL scores in different COPD grades were compared by linear regression models adjusting for age, sex, education, smoking status, BMI, and low vs. high number of comorbidities or a list of several self-reported comorbid conditions. Discriminative abilities of HRQL instruments to differentiate between COPD grades were assessed by standardized mean differences.
resultsIn 2,291 subjects in COPD GOLD grades 1-4 EQ-5D-3 L utility, EQ-5D VAS, SGRQ, and CAT were found able to discriminate between COPD grades, with some limitations for the EQ-5D utility in mild disease. Both generic and disease-specific HRQL instruments reflected the burden of comorbid conditions. The SGRQ showed the best discrimination between COPD grades and was less influenced by comorbidities, while EQ-5D utility put a higher weight on comorbid conditions. For all instruments, psychiatric disorders and peripheral artery disease showed the strongest negative associations with HRQL.
conclusionAll HRQL instruments considered reflect considerable impairment of HRQL in COPD patients, worsening with increasing COPD grade and number of comorbidities. Findings may support clinical assessment, choice of HRQL instrument in future studies, and parameterization of decision-analytic models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.