ArticleParasites & vectors2016
Borrelia persica infection in dogs and cats: clinical manifestations, clinicopathological findings and genetic characterization.
Article in Parasites & vectors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Exposure in Horses to Human Tick-Borne Relapsing Fever Agent Borrelia persica, Israel, 2025.Emerging infectious diseases · 2026Article
- Borrelial Diseases Across Eurasia.Biology · 2025Review
- Lyme disease in companion animals: an updated state-of-art and current situation in Portugal.Veterinary research communications · 2024Review
- Prevalence of Lyme Disease and Relapsing FeverPathogens (Basel, Switzerland) · 2024Review
- Isolation and Genetic Characterization of the Human Relapsing Fever SpirocheteTransboundary and emerging diseases · 2024Article
- Borrelia persica infection in wild carnivores in Israel: molecular characterization and new potential reservoirs.Parasites & vectors · 2023Article
- Historical overview and update on relapsing fever group Borrelia in Latin America.Parasites & vectors · 2022Review
- Infection and seroprevalence of Borrelia persica in domestic cats and dogs in Israel.Parasites & vectors · 2022Article
- Review
- Transmission of the Human Relapsing Fever Spirochete Borrelia persica by the Argasid Tick Ornithodoros tholozani Involves Blood Meals from Wildlife Animal Reservoirs and Mainly Transstadial Transfer.Applied and environmental microbiology · 2021Article
- Seroprevalence and associated risk factors for vector-borne pathogens in dogs from Egypt.Parasites & vectors · 2021Article
- Hematological Features in Sheep with IgG and IgM Antibodies againstPathogens (Basel, Switzerland) · 2021Article
- Rodent Ectoparasites in the Middle East: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2021Review
- First Cases of Natural Infections withMicroorganisms · 2020Article
- A new piroplasmid species infecting dogs: morphological and molecular characterization and pathogeny of Babesia negevi n. sp.Parasites & vectors · 2020Article
- Rapid clearance of Borrelia burgdorferi from the blood circulation.Parasites & vectors · 2020Article
- Role of vector-borne pathogens in the development of fever in cats: 2. Tick- and sandfly-associated diseases.Journal of feline medicine and surgery · 2020Review
- Tick-borne relapsing fever as a potential veterinary medical problem.Veterinary medicine and science · 2018Review
- ACVIM consensus update on Lyme borreliosis in dogs and cats.Journal of veterinary internal medicine · 2018Article
- Relapsing Fevers: Neglected Tick-Borne Diseases.Frontiers in cellular and infection microbiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRelapsing fever (RF) is an acute infectious disease caused by arthropod-borne spirochetes of the genus Borrelia. The disease is characterized by recurrent episodes of fever that concur with spirochetemia. The RF borrelioses include louse-borne RF caused by Borrelia recurrentis and tick-borne endemic RF transmitted by argasid soft ticks and caused by several Borrelia spp. such as B. crocidurae, B. coriaceae, B. duttoni, B. hermsii, B. hispanica and B. persica. Human infection with B. persica is transmitted by the soft tick Ornithodoros tholozani and has been reported from Iran, Israel, Egypt, India, and Central Asia.
methodsDuring 2003-2015, five cats and five dogs from northern, central and southern Israel were presented for veterinary care and detected with borrelia spirochetemia by blood smear microscopy. The causative infective agent in these animals was identified and characterized by PCR from blood and sequencing of parts of the flagellin (flab), 16S rRNA and glycerophosphodiester phosphodiestrase (GlpQ) genes.
resultsAll animals were infected with B. persica genetically identical to the causative agent of human RF. Phylogenetic analysis indicated that DNA sequences from these pet carnivores clustered together with B. persica genotypes I and II from humans and O. tholozani ticks and distinctly from other RF Borrelia spp. The main clinical findings in cats included lethargy, anorexia, anemia in 5/5 cats and thrombocytopenia in 4/5. All dogs were lethargic and anorectic, 4/5 were febrile and anemic and 3/5 were thrombocytopenic. Three dogs were co-infected with Babesia spp. The animals were all treated with antibiotics and the survival rate of both dogs and cats was 80 %. The cat and dog that succumbed to disease died one day after the initiation of antibiotic treatment, while survival in the others was followed by the rapid disappearance of spirochetemia.
conclusionsThis is the first report of disease due to B. persica infection in cats and the first case series in dogs. Infection was associated with anemia and thrombocytopenia. Fever was more frequently observed in dogs than cats. Domestic canines and felines suffer from clinical disease due to B. persica infection and may also serve as sentinels for human infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.