ArticleScientific reports2016
Taste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domains.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Molecular Recognition and Modification Strategies of Umami Dipeptides with T1R1/T1R3 Receptors.Molecules (Basel, Switzerland) · 2025Article
- Sweet flavor compounds produced by the endophytic fungusFood science and biotechnology · 2025Article
- Evolutionary history of calcium-sensing receptors unveils hyper/hypocalcemia-causing mutations.PLoS computational biology · 2024Article
- Article
- Direct binding of calmodulin to the cytosolic C-terminal regions of sweet/umami taste receptors.Journal of biochemistry · 2023Article
- Allosteric modulation of the fish taste receptor type 1 (T1R) family by the extracellular chloride ion.Scientific reports · 2023Article
- Zebrafish and medaka T1R (taste receptor type 1) proteins mediate highly sensitive recognition of l-proline.FEBS open bio · 2023Article
- Article
- Pharmacology of TAS1R2/TAS1R3 Receptors and Sweet Taste.Handbook of experimental pharmacology · 2022Article
- Biophysical and functional characterization of the human TAS1R2 sweet taste receptor overexpressed in a HEK293S inducible cell line.Scientific reports · 2021Article
- Probing Interdomain Linkers and Protein Supertertiary Structure In Vitro and in Live Cells with Fluorescent Protein Resonance Energy Transfer.Journal of molecular biology · 2021Article
- Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.Journal of molecular neuroscience : MN · 2021Review
- Insights into the Function and Evolution of Taste 1 Receptor Gene Family in the Carnivore Fish Gilthead Seabream (International journal of molecular sciences · 2020Article
- Evaluation of Sweetener Synergy in Humans by Isobole Analyses.Chemical senses · 2019Review
- Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits.The Journal of biological chemistry · 2019Article
- SDS-induced oligomerization of Lys49-phospholipase AScientific reports · 2019Article
- Article
- Structure-Function Relationships of Olfactory and Taste Receptors.Chemical senses · 2018Review
- A large-scale expression strategy for multimeric extracellular protein complexes using Drosophila S2 cells and its application to the recombinant expression of heterodimeric ligand-binding domains of taste receptor.Protein science : a publication of the Protein Society · 2017Article
- Structural basis for perception of diverse chemical substances by T1r taste receptors.Nature communications · 2017Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sweet and umami tastes are perceived by T1r taste receptors in oral cavity. T1rs are class C G-protein coupled receptors (GPCRs), and the extracellular ligand binding domains (LBDs) of T1r1/T1r3 and T1r2/T1r3 heterodimers are responsible for binding of chemical substances eliciting umami or sweet taste. However, molecular analyses of T1r have been hampered due to the difficulties in recombinant expression and protein purification, and thus little is known about mechanisms for taste perception. Here we show the first molecular view of reception of a taste substance by a taste receptor, where the binding of the taste substance elicits a different conformational state of T1r2/T1r3 LBD heterodimer. Electron microscopy has showed a characteristic dimeric structure. Förster resonance energy transfer and X-ray solution scattering have revealed the transition of the dimerization manner of the ligand binding domains, from a widely spread to compactly organized state upon taste substance binding, which may correspond to distinct receptor functional states.
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