ArticleBrain stimulation
Anterior Thalamic Deep Brain Stimulation: Functional Activation Patterns in a Large Animal Model.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- A potential therapeutic role of unilateral anterior thalamic deep brain stimulation in epileptic spasms: A case report.Epilepsy & behavior reports · 2026Article
- Mechanism and progress of deep brain stimulation in the treatment of neurological and psychiatric disorders.MedScience · 2026Review
- A method for analyzing the ERP associated with high frequency ANT DBS offset.Computational and structural biotechnology journal · 2025Article
- Improving the effectiveness of ANT DBS therapy for epilepsy with optimal current targeting.Epilepsia open · 2020Article
- The anterior and medial thalamic nuclei and the human limbic system: tracing the structural connectivity using diffusion-weighted imaging.Scientific reports · 2020Article
- Deep brain stimulation of the anterior nucleus of the thalamus for drug-resistant epilepsy.Neurosurgical review · 2019Review
- Multichannel Silicon Probes for Awake Hippocampal Recordings in Large Animals.Frontiers in neuroscience · 2019Article
- Considering the Evidence for Anterior and Laterodorsal Thalamic Nuclei as Higher Order Relays to Cortex.Frontiers in molecular neuroscience · 2019Review
- A novel re-attachable stereotactic frame for MRI-guided neuronavigation and its validation in a large animal and human cadaver model.Journal of neural engineering · 2018Article
- Acute pressure changes in the brain are correlated with MR elastography stiffness measurements: initial feasibility in an in vivo large animal model.Magnetic resonance in medicine · 2018Article
- fMRI-Based Brain Responses to Quinine and Sucrose Gustatory Stimulation for Nutrition Research in the Minipig Model: A Proof-of-Concept Study.Frontiers in behavioral neuroscience · 2018Article
- Bilateral stereotactic lesions and chronic stimulation of the anterior thalamic nuclei for treatment of pharmacoresistant epilepsy.Surgical neurology international · 2018Article
- Executive Functions May Predict Outcome in Deep Brain Stimulation of Anterior Nucleus of Thalamus for Treatment of Refractory Epilepsy.Frontiers in neurology · 2018Article
- Correction of metal-induced susceptibility artifacts for functional MRI during deep brain stimulation.NeuroImage · 2017Article
- Functional Circuitry Effect of Ventral Tegmental Area Deep Brain Stimulation: Imaging and Neurochemical Evidence of Mesocortical and Mesolimbic Pathway Modulation.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDeep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) exerts its effects by modulating neural circuits involved in seizures. However, these networks remain incompletely characterized.
objectiveInvestigate the effects of ATN DBS on network activity in a large animal model using 3-T fMRI.
methodsAnesthetized swine underwent ATN DBS using stimulation parameters applied in the Stimulation of the Anterior Thalamus for the Treatment of Epilepsy (SANTE) trial. Stimulation amplitude, frequency, and temporal paradigm were varied and the resulting blood oxygen level-dependent signal was measured.
resultsATN DBS resulted in activation within temporal, prefrontal, and sensorimotor cortex. An amplitude-dependent increase in cluster volume was observed at 60 Hz and 145 Hz stimulation.
conclusionATN DBS in swine induced parameter-dependent activation in cortical regions including but not limited to the Papez circuit. These findings may hold clinical implications for treatment of epilepsy in patients with temporal or extratemporal seizure foci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.