ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2016
Flow Diversion for Intracranial Aneurysm Management: A New Standard of Care.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Endovascular management of internal carotid artery terminus aneurysms: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Trends of Expanding Indications of Woven EndoBridge Devices for the Treatment of Intracranial Aneurysms: A Systematic Review and Meta-analysis.Clinical neuroradiology · 2023Pooled it
- Efficacy of pipeline embolization device vs. traditional coils in embolization of intracranial aneurysms: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Efficacy and safety of flow diverters in posterior circulation aneurysms and comparison with their efficacy in anterior circulation aneurysms: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021Pooled it
- Comparison of the efficacy and safety of flow diversion versus stent-assisted coiling in posterior circulation aneurysms: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Clinical Outcomes and Device-Related Complications Following Flow Diverter Stent Treatment of Unruptured Intracranial Aneurysms: A Single-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
- First clinical experience with the surpass elite flow diverter in the treatment of intracranial aneurysms.Neuroradiology · 2026Article
- Impact of angiotensin-converting-enzyme inhibitors on intracranial aneurysm endovascular treatment outcome.Neuroradiology · 2026Observational
- Efficacy and Safety in the Use of Pipeline Vantage Shield Stent versus Pipeline Flex Shield Stent in the Treatment of Patients with Unruptured Intracranial Aneurysms: A Multicenter Study.AJNR. American journal of neuroradiology · 2025Article
- Flow-Diverting Stents During Mechanical Thrombectomy for Carotid Artery Dissection-Related Stroke: Analysis from a Multicentre Cohort.Brain sciences · 2025Article
- Cranial and spinal computed tomography (CT) angiography with photon-counting detector CT: comparison with angiographic and operative findings.Japanese journal of radiology · 2025Review
- Poly(2-methoxyethyl acrylate) (PMEA) improves the thromboresistance of FRED flow diverters: a thrombogenic evaluation of flow diverters with human blood under flow conditions.Journal of neurointerventional surgery · 2023Article
- Dynamic interaction nursing intervention on functional rehabilitation and self-care ability of patients after aneurysm surgery.World journal of clinical cases · 2022Article
- Microcatheter-guided compartment packing of acutely ruptured complex intracerebral aneurysms (ARCIAs): Preliminary experience and technical note.Frontiers in neurology · 2022Article
- Progressive volume reduction and long-term aneurysmal collapse following flow diversion treatment of giant and symptomatic cerebral aneurysms.Frontiers in neurology · 2022Article
- Bailout Strategies and Complications Associated with the Use of Flow-Diverting Stents for Treating Intracranial Aneurysms.Interventional neurology · 2020Review
- Advances in endovascular aneurysm management: flow modulation techniques with braided mesh devices.Stroke and vascular neurology · 2020Review
- Single-Center Experience With the Bare p48MW Low-Profile Flow Diverter and Its Hydrophilically Covered Version for Treatment of Bifurcation Aneurysms in Distal Segments of the Anterior and Posterior Circulation.Frontiers in neurology · 2020Article
- Mid-term follow-up of staged bilateral internal carotid artery aneurysm treatment with Pipeline embolization.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2019Article
- Delayed Stroke after Aneurysm Treatment with Flow Diverters in Small Cerebral Vessels: A Potentially Critical Complication Caused by Subacute Vasospasm.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endovascular treatment of intracranial aneurysms with complex morphologies such as giant, wide-necked, or fusiform aneurysms is challenging. Stent-assisted coiling and balloon-assisted coiling are alternative techniques to treat such complex aneurysms, but studies have shown less-than-expected efficacy, as suggested by their high rate of recanalization. The management of complex aneurysms via microsurgery or conventional neuroendovascular strategies has traditionally been poor. However, over the last few years, flow-diverting stents (FDS) have revolutionized the treatment of such aneurysms. FDS are implanted within the parent artery rather than the aneurysm sac. By modifying intra-aneurysmal and parent-vessel flow dynamics at the aneurysm/parent vessel interface, FDS trigger a cascade of gradual intra-aneurysmal thrombosis. As endothelialization of the FDS is complete, the parent vessel reconstructs while preserving the patency of normal perforators and side branch vessels. As with any intervention, the practice and application of flow-diversion technology is inherent, with risks that include vessel rupture or perforation, in-stent thrombosis, perforator occlusion, procedural and delayed hemorrhages, and perianeurysmal edema. Herein, we review the devices, their mechanisms of actions, clinical applications, complications, and ongoing studies.
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