Evidence map›Paper›PMID 27160185›Full record

ArticleEuropean biophysics journal : EBJ2016

Sigma-1 receptors modulate neonatal Na

Ebru Aydar, Dan Stratton, Scott P Fraser, Mustafa B A Djamgoz, Christopher Palmer

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European biophysics journal : EBJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Effects of NaCell biochemistry and biophysics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ebru AydarInstitute of Ophthalmology, University College London, 11/43 Bath Street, London, EC1V 9EL, UK.
Dan StrattonFaculty of Life Sciences, London Metropolitan University, London, N7 8DB, UK.
Scott P FraserNeuroscience Solutions to Cancer Research Group, Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, London, SW7 2AZ, UK.
Mustafa B A DjamgozNeuroscience Solutions to Cancer Research Group, Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, London, SW7 2AZ, UK.
Christopher PalmerFaculty of Life Sciences, London Metropolitan University, London, N7 8DB, UK. chris.palmer@londonmet.ac.uk.
Imperial College London · GBLondon Metropolitan University · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main aim of this study was to investigate a possible functional connection between sigma-1 receptors and voltage-gated sodium channels (VGSCs) in human breast cancer cells. The hypothesis was that sigma-1 drugs could alter the metastatic properties of breast cancer cells via the VGSC. Evidence was found for expression of sigma-1 receptor and neonatal Na

Indexed as

Breast NeoplasmsCell AdhesionCell Line, TumorCell MovementCell ProliferationGene SilencingHumansInfant, NewbornNAV1.5 Voltage-Gated Sodium ChannelNeoplasm MetastasisReceptors, sigmaSigma-1 ReceptorNAV1.5 Voltage-Gated Sodium ChannelReceptors, sigmaSCN5A protein, humanSigma-1 ReceptorMetastasisSigma-1 receptorSodium channel

Identifiers

PMID27160185
OpenAlexW2345609527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.