Evidence map›Paper›PMID 27160096›Full record

ArticleHistochemistry and cell biology2016

Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells.

Ryuta Murakami, Yoichi Chiba, Kazuhito Tsuboi, Koichi Matsumoto, Machi Kawauchi, Ryuji Fujihara, Masato Mashima, Kenji Kanenishi, Tetsuji Yamamoto, Masaki Ueno

Abstract read
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In one paragraph

Article in Histochemistry and cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium.International journal of molecular sciences · 2020
    Review
  8. Glucose transporters in brain in health and disease.Pflugers Archiv : European journal of physiology · 2020
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ryuta MurakamiDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho (Kita-gun), Kagawa, 761-0793, Japan.
Yoichi ChibaDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho (Kita-gun), Kagawa, 761-0793, Japan.
Kazuhito TsuboiDepartment of Biochemistry, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa, 761-0793, Japan.
Koichi MatsumotoDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho (Kita-gun), Kagawa, 761-0793, Japan.
Machi KawauchiDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho (Kita-gun), Kagawa, 761-0793, Japan.
Ryuji FujiharaDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho (Kita-gun), Kagawa, 761-0793, Japan.
Masato MashimaDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho (Kita-gun), Kagawa, 761-0793, Japan.
Kenji KanenishiDepartment of Perinatology and Gynecology, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa, 761-0793, Japan.
Tetsuji YamamotoDepartment of Orthopaedic Surgery, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa, 761-0793, Japan.
Masaki UenoDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho (Kita-gun), Kagawa, 761-0793, Japan. masaueno@med.kagawa-u.ac.jp.
Kagawa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High fructose intake is known to be associated with increased plasma triglyceride concentration, impaired glucose tolerance, insulin resistance, and high blood pressure. In addition, excess fructose intake is also thought to be a risk factor for dementia. Previous immunohistochemical studies have shown the presence of glucose transporter 5 (GLUT5), a major transporter of fructose, in the epithelial cells of the choroid plexus and ependymal cells in the brains of humans, rats, and mice, while GLUT2, a minor transporter of fructose, was localized in the ependymal cells of rat brain. In this study, immunoreactivity for the fructose transporter GLUT8 was observed in the cytoplasm of the epithelial cells in the choroid plexus and in the ependymal cells of the brains of humans and mice. These structures were not immunoreactive for GLUT7, GLUT11, and GLUT12. Our findings support the hypothesis of the transport of intravascular fructose through the epithelial cells of the choroid plexus and the ependymal cells.

Indexed as

AnimalsChoroid PlexusEpendymaEpithelial CellsGlucose Transport Proteins, FacilitativeHumansImmunohistochemistryMaleMiceMice, Inbred C3HGlucose Transport Proteins, FacilitativeSLC2A8 protein, humanSlc2a8 protein, mouseChoroid plexusEpendymal cellFructoseGLUT8

Identifiers

PMID27160096
OpenAlexW2345990489

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.