Evidence map›Paper›PMID 27159656›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2016

Serum creatinine elevation after switch to dolutegravir in a human immunodeficiency virus-positive kidney transplant recipient.

D H Lee, G E Malat, T E Bias, M N Harhay, K Ranganna, A M Doyle

Abstract readCase Reports
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Observational
  3. Article
  4. Review
  5. Article
  6. Successful optimization of antiretroviral regimens in treatment-experienced people living with HIV undergoing liver transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2019
    Article
  7. Review
  8. Variable Tacrolimus Dosing After Protease Inhibitor-Based Antiretroviral Therapy Discontinuation in 2 HIV Patients Post-Kidney Transplantation.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

D H LeeDivision of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, Pennsylvania, USA.
G E MalatDepartment of Surgery, Drexel University, Philadelphia, Pennsylvania, USA.
T E BiasDivision of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, Pennsylvania, USA.
M N HarhayDivision of Nephrology, Drexel University, Philadelphia, Pennsylvania, USA.
K RangannaDivision of Nephrology, Drexel University, Philadelphia, Pennsylvania, USA.
A M DoyleDivision of Nephrology, Drexel University, Philadelphia, Pennsylvania, USA.

Funding

Patterns and Implications of Functional Decline Among Kidney Transplant CandidatesK23DK105207 · NIDDK · DREXEL UNIVERSITY · PI HARHAY, MEERA NAIR · 2015 to 2019
$861k
NIDDK NIH HHS K23 DK105207
6 · The paper itself

Abstract

Dolutegravir is a preferred antiretroviral drug for human immunodeficiency virus (HIV)-infected patients following solid organ transplantation. It has potent antiretroviral activity and does not interact with calcineurin inhibitors. We describe a case of an HIV-infected kidney transplant patient, who was noted to have a rising serum creatinine following initiation of dolutegravir. At first, an acute rejection episode was suspected, but this finding was later attributed to inhibition of creatinine secretion by dolutegravir. We suggest that an awareness of this potential effect of dolutegravir is important for providers who take care of HIV-positive kidney transplant recipients, in order to prevent potentially unnecessary testing.

Indexed as

Drug SubstitutionAnti-Retroviral AgentsCalcineurin InhibitorsCreatinineDolutegravirDrug InteractionsDrug Therapy, CombinationGraft RejectionHeterocyclic Compounds, 3-RingHIVHIV SeropositivityHumansImmunosuppression TherapyImmunosuppressive AgentsKidney Failure, ChronicKidney TransplantationAnti-Retroviral AgentsCalcineurin InhibitorsCreatinineDolutegravirHeterocyclic Compounds, 3-RingImmunosuppressive AgentsOxazinesPiperazinesPyridonesantiretroviralcreatininedolutegravirhuman immunodeficiency viruskidney transplant

Identifiers

PMID27159656
PMCPMC5525135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.