ArticleHuman brain mapping2016
Physical activity and inflammation: effects on gray-matter volume and cognitive decline in aging.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Current Strategies for Healthy Aging: The Interplay Between Nutrition, Metabolism, and Exercise.Cureus · 2025Review
- Associations between sleep duration, physical activity, and cognitive impairment in older adults-empirical analysis based on CHARLS data.Frontiers in public health · 2025Article
- The moderating role of walking in the association between HDL cholesterol and cognitive function among Korean older adults: a nationwide population-based cross-sectional study.Frontiers in public health · 2025Article
- Exercise Reshapes the Brain: Molecular, Cellular, and Structural Changes Associated with Cognitive Improvements.Molecular neurobiology · 2023Review
- Move Your Body, Boost Your Brain: The Positive Impact of Physical Activity on Cognition across All Age Groups.Biomedicines · 2023Review
- Morphometry of the lateral orbitofrontal cortex is associated with eating dispositions in early adolescence: findings from a large population-based study.Social cognitive and affective neuroscience · 2023Article
- Frailty and its combined effects with lifestyle factors on cognitive function: a cross-sectional study.BMC geriatrics · 2023Article
- Activation of the brain during motor imagination task with auditory stimulation.Frontiers in neuroscience · 2023Article
- Review
- Neurological Symptoms and Their Associations With Inflammatory Biomarkers in the Chronic Phase Following Traumatic Brain Injuries.Frontiers in psychiatry · 2022Article
- Robot Assisted Treatment of Hand Functional Rehabilitation Based on Visual Motor Imagination.Frontiers in aging neuroscience · 2022Article
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults:Aging · 2021Article
- Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging.Behavioural brain research · 2021Review
- Alteration of Behavioral Inhibitory Control in High-Altitude Immigrants.Frontiers in behavioral neuroscience · 2021Article
- Repositioning medication for cardiovascular and cerebrovascular disease to delay the onset and prevent progression of Alzheimer's disease.Archives of pharmacal research · 2020Review
- Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Article
- Accelerometer Physical Activity is Associated with Greater Gray Matter Volumes in Older Adults Without Dementia or Mild Cognitive Impairment.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019Article
- White matter microstructure mediates the association between physical fitness and cognition in healthy, young adults.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical activity has been positively associated with gray-matter integrity. In contrast, pro-inflammatory cytokines seem to have negative effects on the aging brain and have been related to dementia. It was investigated whether an inactive lifestyle and high levels of inflammation resulted in smaller gray-matter volumes and predicted cognitive decline across 6 years in a population-based study of older adults (n = 414). Self-reported physical activity (fitness-enhancing, health-enhancing, inadequate) was linked to gray-matter volume, such that individuals with inadequate physical activity had the least gray matter. There were no overall associations between different pro-and anti-inflammatory markers (IL-1β, IL-6, IL-10, IL-12p40, IL-12p70, G-CSF, and TNF-α) and gray-matter integrity. However, persons with inadequate activity and high levels of the pro-inflammatory marker IL-12p40 had smaller volumes of lateral prefrontal cortex and hippocampus and declined more on the Mini-Mental State Examination test over 6 years compared with physically inactive individuals with low levels of IL-12p40 and to more physically active persons, irrespective of their levels of IL-12p40. These patterns of data suggested that inflammation was particularly detrimental in inactive older adults and may exacerbate the negative effects of physical inactivity on brain and cognition in old age. Hum Brain Mapp 37:3462-3473, 2016. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.