Trial reportCurrent eye research2016
Systemic Absorption of Cyclopentolate and Adverse Events After Retinopathy of Prematurity Exams.
Trial report in Current eye research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03448640 (Efficiency and Safety of Phenylephrine and Tropicamide Used in Premature Retinopathy), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficiency and Safety of Phenylephrine and Tropicamide Used in Premature Retinopathy
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Systematic review of mydriatics used for screening of retinopathy in premature infants.BMJ paediatrics open · 2019Pooled it
- Low dose or very low dose phenylephrine and cyclopentolate microdrops for retinopathy of prematurity eye examinations (The Little Eye Drop Study): a randomised controlled non-inferiority trial.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Pain and sedation management for screening or treatment of retinopathy of prematurity.The Cochrane database of systematic reviews · 2025Article
- The effects of mydriatic eye drops on cerebral blood flow and oxygenation in retinopathy of prematurity examinations.European journal of pediatrics · 2023Article
- Autonomic measures identify stress, pain, and instability associated with retinopathy of prematurity ophthalmologic examinations.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Ocular Cyclopentolate: A Mini Review Concerning Its Benefits and Risks.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- Retinopathy of prematurity screening and risk mitigation during the COVID-19 pandemic.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2021Article
- Ocular Blood Flow in Preterm Neonates: A Preliminary Report.Translational vision science & technology · 2021Article
- Do extremely preterm infants need retinopathy of prematurity screening earlier than 31 weeks postmenstrual age?Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Systemic adverse events after screening of retinopathy of prematurity with mydriatic.PloS one · 2021Article
- Reducing discomfort of eye drops prior to retinal examination in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Efficiency and safety of phenylephrine and tropicamide used in premature retinopathy: a prospective observational study.BMC pediatrics · 2019Observational
- Differential effects of the retinopathy of prematurity exam on the physiology of premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Ocular Refraction at Birth and Its Development During the First Year of Life in a Large Cohort of Babies in a Single Center in Northern Italy.Frontiers in pediatrics · 2019Article
- Effect of pupil dilation on intraocular pressure in preterm and term infants.Arquivos brasileiros de oftalmologiaArticle
- Ocular Biometry in Preterm Newborns in the Neonatal Intensive Care Unit Environment of a Referral Hospital.Ophthalmology scienceArticle
Corrections and comments
- Erratum issuedCorrigendum.2018
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposePreterm infants undergoing Retinopathy of Prematurity Eye Exams (ROPEE) may experience adverse events, possibly from systemic absorption of cyclopentolate. The purpose of this study was to analyze the association between adverse events and drug levels found in neonates undergoing ROPEE. MATERIALS AND
methods25 infants were randomized into two groups during routine ROP screening: 5 infants for blood collection before mydriatic drops and 20 for blood collection 1 h after eye drops. Blood was collected onto dried blood spot cards, extracted, and analyzed for cyclopentolate and phenylephrine using liquid chromatography and mass spectrometry. Relationships between drug levels and adverse events were assessed.
resultsCyclopentolate (range 6-53 ng/ml) was observed in 15 of 18 infants, while phenylephrine was not detected. Levels of cyclopentolate were significantly higher in infants who were on oxygen (p = 0.01). There was a significant association between cyclopentolate levels and gastric residuals in tube-fed infants not receiving oxygen (p = 0.01).
conclusionsCyclopentolate levels varied among preterm infants after ROPEE. Cyclopentolate was positively associated with increased gastric residuals. Underlying medical conditions requiring oxygen administration may affect absorption and metabolism of cyclopentolate. There is a need to predict infants at risk for high blood levels of cyclopentolate in order to prevent or treat adverse events after ROPEE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.