Evidence map›Paper›PMID 27159222›Full record

ArticlePloS one2016

Sphingolipids in Congenital Diaphragmatic Hernia; Results from an International Multicenter Study.

Kitty G Snoek, Irwin K M Reiss, Jeroen Tibboel, Joost van Rosmalen, Irma Capolupo, Arno van Heijst, Thomas Schaible, Martin Post, Dick Tibboel

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Ceramide and Regulation of Vascular Tone.International journal of molecular sciences · 2019
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Kitty G SnoekIntensive Care and Department of Paediatric Surgery, Erasmus Medical Center- Sophia Children's Hospital, Rotterdam, The Netherlands.
Irwin K M ReissDepartment of Neonatology, Erasmus Medical Center- Sophia Children's Hospital, Rotterdam, The Netherlands.
Jeroen TibboelIntensive Care and Department of Paediatric Surgery, Erasmus Medical Center- Sophia Children's Hospital, Rotterdam, The Netherlands.
Joost van RosmalenDepartment of Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
Irma CapolupoDepartment of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital, Rome, Italy.
Arno van HeijstDepartment of Neonatology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Thomas SchaibleDepartment of Neonatology, Universitätsklinikum Mannheim, Mannheim, Germany.
Martin PostProgram of Physiology and Experimental Medicine, Hospital for Sick Children Research Institute, Toronto, Canada.
Dick TibboelIntensive Care and Department of Paediatric Surgery, Erasmus Medical Center- Sophia Children's Hospital, Rotterdam, The Netherlands.
Erasmus MC - Sophia Children’s Hospital · NLBambino Gesù Children's Hospital · ITErasmus MC · NLHospital for Sick Children · CARadboud University Nijmegen · NLUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCongenital diaphragmatic hernia is a severe congenital anomaly with significant mortality and morbidity, for instance chronic lung disease. Sphingolipids have shown to be involved in lung injury, but their role in the pathophysiology of chronic lung disease has not been explored. We hypothesized that sphingolipid profiles in tracheal aspirates could play a role in predicting the mortality/ development of chronic lung disease in congenital diaphragmatic hernia patients. Furthermore, we hypothesized that sphingolipid profiles differ between ventilation modes; conventional mechanical ventilation versus high-frequency oscillation.

methodsSphingolipid levels in tracheal aspirates were determined at days 1, 3, 7 and 14 in 72 neonates with congenital diaphragmatic hernia, born after > 34 weeks gestation at four high-volume congenital diaphragmatic hernia centers. Data were collected within a multicenter trial of initial ventilation strategy (NTR 1310).

results36 patients (50.0%) died or developed chronic lung disease, 34 patients (47.2%) by stratification were initially ventilated by conventional mechanical ventilation and 38 patients (52.8%) by high-frequency oscillation. Multivariable logistic regression analysis with correction for side of the defect, liver position and observed-to-expected lung-to-head ratio, showed that none of the changes in sphingolipid levels were significantly associated with mortality /development of chronic lung disease. At day 14, long-chain ceramides 18:1 and 24:0 were significantly elevated in patients initially ventilated by conventional mechanical ventilation compared to high-frequency oscillation.

conclusionsWe could not detect significant differences in temporal sphingolipid levels in congenital diaphragmatic hernia infants with mortality/development of chronic lung disease versus survivors without development of CLD. Elevated levels of ceramides 18:1 and 24:0 in the conventional mechanical ventilation group when compared to high-frequency oscillation could probably be explained by high peak inspiratory pressures and remodeling of the alveolar membrane.

Indexed as

FemaleHernias, Diaphragmatic, CongenitalHumansInfant, NewbornInternationalityMaleSphingolipidsSphingolipids

Identifiers

PMID27159222
PMCPMC4861280
OpenAlexW2346685283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.