Evidence map›Paper›PMID 27158669›Full record

ArticleJCI insight2016

Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6-deficient process.

Piers E M Patten, Gerardo Ferrer, Shih-Shih Chen, Rita Simone, Sonia Marsilio, Xiao-Jie Yan, Zachary Gitto, Chaohui Yuan, Jonathan E Kolitz, Jacqueline Barrientos and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  8. Article
  9. Chronic Lymphocytic Leukemia.Cold Spring Harbor perspectives in medicine · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Piers E M PattenThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.; King's College London, Department of Haematological Medicine, London, United Kingdom.
Gerardo FerrerThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.
Shih-Shih ChenThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.
Rita SimoneThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.
Sonia MarsilioThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.
Xiao-Jie YanThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.
Zachary GittoThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.
Chaohui YuanDepartment of Applied Mathematics and Statistics, State University of New York, Stony Brook, New York, USA.
Jonathan E KolitzThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.; Department of Medicine, Hofstra Northwell School of Medicine, Manhasset, New York, USA.
Jacqueline BarrientosThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.; Department of Medicine, Hofstra Northwell School of Medicine, Manhasset, New York, USA.
Steven L AllenThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.; Department of Medicine, Hofstra Northwell School of Medicine, Manhasset, New York, USA.
Kanti R RaiThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.; Department of Medicine, Hofstra Northwell School of Medicine, Manhasset, New York, USA.
Thomas MacCarthyDepartment of Applied Mathematics and Statistics, State University of New York, Stony Brook, New York, USA.
Charles C ChuThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.; Department of Medicine, Hofstra Northwell School of Medicine, Manhasset, New York, USA.; Department of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, New York, USA.
Nicholas ChiorazziThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.; Department of Medicine, Hofstra Northwell School of Medicine, Manhasset, New York, USA.; Department of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, New York, USA.
Feinstein Institute for Medical Research · USNorthwell Health · USState University of New York · USStony Brook University · US

Funding

B CELL REPERTOIRES IN CHRONIC LYMPHOCYTIC LEUKEMIAR01CA081554 · NCI · NORTH SHORE UNIVERSITY HOSPITAL · PI CHIORAZZI, NICHOLAS · 2000 to 2012
$2.7M
High-throughput informatics for antibodiesR01GM111741 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI MACCARTHY, THOMAS · 2015 to 2018
$1.1M
NCI NIH HHS R01 CA081554NIGMS NIH HHS R01 GM111741
6 · The paper itself

Abstract

Xenografting primary tumor cells allows modeling of the heterogeneous natures of malignant diseases and the influences of the tissue microenvironment. Here, we demonstrate that xenografting primary chronic lymphocytic leukemia (CLL) B lymphocytes with activated autologous T cells into alymphoid mice results in considerable CLL B cell division and sizable T cell expansion. Nevertheless, most/all CD5

Identifiers

PMID27158669
PMCPMC4855875
OpenAlexW2324641152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.