Evidence map›Paper›PMID 27158641›Full record

ArticleTechnology2015

Microwell arrays reveal cellular heterogeneity during the clonal expansion of transformed human cells.

Tim C Chang, Weiliang Tang, William Jen Hoe Koh, Alexander J E Rettie, Mary J Emond, Raymond J Monnat, Albert Folch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. 'AnbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tim C ChangDepartments of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Weiliang TangDepartments of Pathology, University of Washington, Seattle, WA 98195, USA.
William Jen Hoe KohDepartments of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Alexander J E RettieDepartments of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Mary J EmondDepartments of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Raymond J MonnatDepartments of Pathology, University of Washington, Seattle, WA 98195, USA; Departments of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Albert FolchDepartments of Bioengineering, University of Washington, Seattle, WA 98195, USA.
University of Washington · US

Funding

Tumor mutation signaturesP01CA077852 · NCI · UNIVERSITY OF WASHINGTON · PI MONNAT, RAYMOND J · 1999 to 2019
$26.0M
NCI NIH HHS P01 CA077852
6 · The paper itself

Abstract

We developed micromolded microwell arrays to study the proliferation and senescence of single cells. Microwell arrays were designed to be compatible with conventional cell culture protocols to simplify cell loading, cell culture, and imaging. We demonstrated the utility of these arrays by measuring the proliferation and senescence of isogenic cells which expressed or had been depleted of the human Werner syndrome protein. Our results allowed us to reveal cell-to-cell heterogeneity in proliferation in WRN+ and WRN-depleted fibroblasts during clonal growth.

Identifiers

PMID27158641
PMCPMC4854201
OpenAlexW2139674417

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.