ArticleInternational journal of ophthalmology2016
Corneal biomechanical changes and intraocular pressure in patients with thyroid orbitopathy.
Article in International journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Biomechanical changes of the cornea after orbital decompression in thyroid-associated orbitopathy measured by corvis ST.Scientific reports · 2024Observational
- The Changes in Ocular Biomechanical Response Parameters and Intraocular Pressure After Surgical Treatment for Thyroid Eye Disease.Investigative ophthalmology & visual science · 2023Article
- Evaluation of the corneal biomechanical properties and corneal thickness in patients with Graves' orbitopathy.International ophthalmology · 2023Article
- The Effect of Thyroid Eye Disease on Corneal Biomechanical Properties.Beyoglu eye journal · 2022Article
- Correlation between corneal thickness, keratometry, age, and differential pressure difference in healthy eyes.Scientific reports · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the relevance of the objective parameters addressing the altered biomechanical properties of cornea for glaucoma monitoring in patients with mild or moderate thyroid associated orbitopathy (TAO), and in healthy individuals.
methodsTwenty-five patients with TAO (group 1) and 25 healthy adults (group 2) were included to the study. Both groups were of a similar age and the ratio women:man. For each patient, the following parameters of both eyes were measured with ocular response analyzer (ORA): corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc). In both groups participating in our study, all measurements were performed within minutes to reduce the diurnal effects.
resultsThe mean age in group 1 was 56±11y and 76% were women, 24% were men. The mean age in group 2 was 64±11y and 68% were women, 32% were men. CH correlated negatively with IOPg in group 1 (r (2)=0.10, P<0.05). IOPg strongly correlated with IOPcc in both groups (group 1: r (2)=0.79, P<0.0001; group 2: r (2)=0.85, P<0.0001). There was positive correlation between CRF and IOPg in group 1 (r (2)=0.12, P<0.05) and in group 2 (r (2)=0.31, P<0.0001). Statistical analysis revealed no significant correlation between CRF and IOPcc in group 1 (r (2)=0.009, P>0.05) and also no significant correlation in group 2 (r (2)=0.04, P>0.05). CRF mean value in group 2 (11.51±1.72 mm Hg) was higher than in group 1 (10.85±1.45 mm Hg) (P<0.05). IOPg strongly correlated with IOPcc in both groups (group 1: r (2)=0.79, P<0.0001; group 2: r (2)=0.85, P<0.0001). There was also strong correlation between CRF and CH in both populations: group 1: (r (2)=0.58, P<0.0001), group 2: (r (2)=0.41, P<0.0001).
conclusionBiomechanical parameters of cornea, as quantified by CH and CRF, and measured together with IOPcc, precisely reveal glaucoma staging in TAO and thus are reliable for diagnosing and follow-up in clinical practice.
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