Evidence map›Paper›PMID 27158559›Full record

ArticleJournal of stem cell research & therapy2016

Mechanisms and Developmental Roles of Promoter-proximal Pausing of RNA Polymerase II.

Christine Robinson, Matthew Lowe, Amanda Schwartz, Nobuaki Kikyo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stem cell research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. [7SK truncation at 128-179 nt suppresses embryonic stem cell proliferationNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christine RobinsonStem Cell Institute, Department of Genetics, Cell Biology and Development, University of Minnesota, USA.
Matthew LoweStem Cell Institute, Department of Genetics, Cell Biology and Development, University of Minnesota, USA.
Amanda SchwartzStem Cell Institute, Department of Genetics, Cell Biology and Development, University of Minnesota, USA.
Nobuaki KikyoStem Cell Institute, Department of Genetics, Cell Biology and Development, University of Minnesota, USA.
University of Minnesota · US

Funding

Histone isomerization and pluripotencyR01GM098294 · NIGMS · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2012 to 2015
$1.1M
Stem Cell Biology Training ProgramT32GM113846 · NIGMS · UNIVERSITY OF MINNESOTA · PI PERLINGEIRO, RITA C. R. · 2015 to 2019
$712k
Long Noncoding RNA and MyogenesisR21AR066158 · NIAMS · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2015 to 2016
$368k
Hypoxia and long noncoding RNAR21CA187232 · NCI · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2014 to 2015
$364k
NCI NIH HHS R21 CA187232NIAMS NIH HHS R21 AR066158NIGMS NIH HHS R01 GM098294NIGMS NIH HHS T32 GM113846
6 · The paper itself

Abstract

RNA polymerase II (Pol II) temporarily stops transcription after synthesizing 30-50 bases, and resumes elongation only after stimulations by various signaling molecules and developmental cues. This phenomenon, called promoter-proximal pausing, is observed in 10-50% of the entire genes from

Indexed as

7SK snRNPDifferentiationGene expressionPromoterP-TEFbRNA polymerase IIStem cells

Identifiers

PMID27158559
PMCPMC4855949
OpenAlexW2412414959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.