ArticleBMJ open diabetes research & care2016
Influence of age on the prevalence and components of the metabolic syndrome and the association with cardiovascular disease.
Article in BMJ open diabetes research & care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05031299 (Lifestyle-related Early Detection and Intervention for Older Adults & Elderly at Risk for Metabolic Syndrome), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lifestyle-related Early Detection and Intervention for Older Adults & Elderly at Risk for Metabolic Syndrome: GATEKEEPER
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Pooled it
- Personalized versus generic digital weight loss interventions delivered on university campuses: a 6-month cost-benefit analysis.Translational behavioral medicine · 2023Trial
- Physical Activity and Cardiometabolic Risk Factor Clustering in Young Adults with Obesity.Medicine and science in sports and exercise · 2020Trial
- High prevalence of low vitamin D status in the Czech Republic: a retrospective study of 119,925 participants.European journal of clinical nutrition · 2025Article
- Risk of Cardiovascular Events Associated with Chronic Obstructive Pulmonary Disease and/or Metabolic Syndrome: A Large-Scale Nationwide Population-Based Cohort Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Sex-specific-evaluation of metabolic syndrome prevalence in Algeria: insights from the 2016-2017 non-communicable diseases risk factors survey.Scientific reports · 2023Article
- Role of gender in explaining metabolic syndrome risk factors in an Iranian rural population using structural equation modelling.Scientific reports · 2023Article
- Identification of a Link between Suspected Metabolic Syndrome and Cognitive Impairment within Pharmaceutical Care in Adults over 75 Years of Age.Healthcare (Basel, Switzerland) · 2023Article
- Independent factors affecting hemorrhagic and ischemic stroke in patients aged 40-69 years: a cross-sectional study.BMC cardiovascular disorders · 2022Article
- Reported organic food consumption and metabolic syndrome in older adults: cross-sectional and longitudinal analyses.European journal of nutrition · 2022Article
- Non-alcoholic fatty liver disease frequency and associated factors at admission of acute stroke.Hepatology international · 2022Article
- Increased risk of incident gout in young men with metabolic syndrome: A nationwide population-based cohort study of 3.5 million men.Frontiers in medicine · 2022Article
- Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis.Frontiers in endocrinology · 2022Article
- Prevalence and Risk Factors of Metabolic Syndrome among the Homeless in Taipei City: A Cross-Sectional Study.International journal of environmental research and public health · 2021Article
- Nutritional and lifestyle intervention strategies for metabolic syndrome in Southeast Asia: A scoping review of recent evidence.PloS one · 2021Article
- The Age-Dependent Increase of Metabolic Syndrome Requires More Extensive and Aggressive Non-Pharmacological and Pharmacological Interventions: A Cross-Sectional Study in an Italian Cohort of Obese Women.International journal of endocrinology · 2021Article
- Cardiometabolic Risk Factors leading to Diabetes Mellitus among the Young (YOD) from the 8Journal of the ASEAN Federation of Endocrine Societies · 2021Article
- The Racial Disparities in the Epidemic of Metabolic Syndrome With Increased Age: A Study From 28,049 Chinese and American Adults.Frontiers in public health · 2021Article
- Differential Effect of the Metabolic Syndrome on the Incidence of Retinal Vein Occlusion in the Korean Population: A Nationwide Cohort Study.Translational vision science & technology · 2020Article
- An analysis of the correlation between thyroid nodules and metabolic syndrome.Endocrine connections · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe significance of the metabolic syndrome (MS) is debated. We investigated whether MS component (by ATPIII and IDF definitions) clustering and any association between MS and prevalent cardiovascular disease (CVD) varied with age. RESEARCH DESIGN AND
methodsIn all, 1429 adults (≥25 years) from randomly selected households in rural Victoria, Australia, were assessed for components of MS and prevalent CVD. The expected prevalence of MS was calculated following a simple probabilistic model using the prevalence of each MS component.
resultsThe observed prevalence of MS was greater than expected: 27.0% vs 21.2% (ATPIII) and 36.0% vs 30.1% (IDF; p<0.0001), based on the prevalence of individual components. There was significant clustering of 4 and 5 MS components in participants <65 years (p<0.0001). CVD was more prevalent in MS participants, 13.5% (IDF), 14.5% (ATPIII) versus 5.3% (no MS) p<0.0001. The OR for CVD in MS participants was greatest in those <45 years OR (95% CI): IDF 17.5 (1.8 to 172); ATPIII 24.3(2.4 to 241), p<0.001 for both, and was not significant in those >65 years. The prevalence of MS (ATPIII) with normal waist circumference (WC) was less than expected (4.8% vs 7.9%, p<0.002). Low levels of high-density lipoprotein and high triglyceride were less common in older MS participants.
conclusionsATPIII MS is rare among those with a normal WC. MS components cluster most markedly among those aged <65 years, who also experience substantially greater rates of CVD. Younger patients with MS may warrant more aggressive CVD preventative treatment than suggested by the summation of their individual risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.