ArticleNew microbes and new infections2016
Diversity of viruses in Ixodes ricinus, and characterization of a neurotropic strain of Eyach virus.
Article in New microbes and new infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 61 citations in OpenAlex.
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- Vectorial dynamics underpinning current and future tick-borne virus emergence in Europe.The Journal of general virology · 2024Review
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- Diversity Analysis of Tick-Borne Viruses from Hedgehogs and Hares in Qingdao, China.Microbiology spectrum · 2023Article
- A Search for Tick-Associated, Bronnoya-like Virus Spillover into Sheep.Microorganisms · 2023Article
- Diversity of Viruses inTransboundary and emerging diseases · 2023Article
- Hazard potential of Swiss Ixodes ricinus ticks: Virome composition and presence of selected bacterial and protozoan pathogens.PloS one · 2023Article
- What do we know about the microbiome ofFrontiers in cellular and infection microbiology · 2022Review
- Discovery and Surveillance of Tick-Borne Pathogens.Journal of medical entomology · 2021Article
- Sequence diversity and evolution of a group of iflaviruses associated with ticks.Archives of virology · 2021Article
- Exploration of theVirus evolution · 2021Article
- Failed Disruption of Tick Feeding, Viability, and Molting after Immunization of Mice and Sheep with RecombinantVaccines · 2020Article
- Viromics on Honey-Baited FTA Cards as a New Tool for the Detection of Circulating Viruses in Mosquitoes.Viruses · 2020Article
- RNA Viruses ofViruses · 2020Article
- Newly identified viral genomes in pangolins with fatal disease.Virus evolution · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ticks transmit more pathogens-including bacteria, parasites and viruses-than any other arthropod vector. Although the epidemiological status of many tick-borne bacteria is very well characterized, tick-borne viruses are still relatively under-studied. Recently, several novel tick-borne viruses have been isolated from human febrile illnesses following tick bites, indicating the existence of other potential new and unknown tick-borne viruses. We used high-throughput sequencing to analyse the virome of Ixodes ricinus, the main vector of tick-borne pathogens in Europe. The majority of collected viral sequences were assigned to two potentially novel Nairovirus and Phlebovirus viruses, with prevalence rates ranging from 3.95% to 23.88% in adults and estimated to be between 0.14% and 72.16% in nymphs. These viruses could not be isolated from the brains of inoculated immunocompromised mice, perhaps indicating that they are unable to infect vertebrates. Within the I. ricinus virome, we also identified contigs with >90% identity to the known Eyach virus. Initially isolated in the 1980s, this virus was indirectly associated with human disease, but had never been extensively studied. Eyach virus prevalence varied between 0.07% and 5.26% in ticks from the French Ardennes and Alsace regions. Eyach virus was successfully isolated following intracerebral inoculation of immunocompromised mice with Eyach virus-positive tick extracts. This virus was also able to multiply and persist in the blood of immunocompetent mice inoculated by intraperitoneal injection, and caused brain infections in three of nine juveniles, without any obvious deleterious effects.
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