ArticleIUCrJ2016
Protein structure determination by single-wavelength anomalous diffraction phasing of X-ray free-electron laser data.
Article in IUCrJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Assessing the problem of excitation light scattering in high-viscosity jets used in serial crystallography sample delivery.Journal of applied crystallography · 2025Article
- Standard Sample Preparation for Serial Femtosecond Crystallography.Biomolecules · 2025Review
- Effect of crystal-to-detector distance shift on data processing in serial crystallography.PloS one · 2025Article
- Sheet-on-sheet fixed target data collection devices for serial crystallography at synchrotron and XFEL sources.Journal of applied crystallography · 2024Article
- Engineering Supramolecular Hybrid Architectures with Directional Organofluorine Bonds.Small science · 2024Article
- XFEL Microcrystallography of Self-Assembling SilverJournal of the American Chemical Society · 2023Article
- Growing and making nano- and microcrystals.Nature protocols · 2023Review
- Article
- Serial femtosecond crystallography.Nature reviews. Methods primers · 2022Article
- Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX.IUCrJ · 2022Article
- Article
- Ultrafast dynamics and scattering of protic ionic liquids induced by XFEL pulses.Journal of synchrotron radiation · 2021Article
- Discerning best practices in XFEL-based biological crystallography - standards for nonstandard experiments.IUCrJ · 2021Review
- Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals.Acta crystallographica. Section D, Structural biology · 2021Article
- The copper(II)-binding tripeptide GHK, a valuable crystallization and phasing tag for macromolecular crystallography.Acta crystallographica. Section D, Structural biology · 2020Article
- Article
- Article
- High-throughput in situ experimental phasing.Acta crystallographica. Section D, Structural biology · 2020Article
- Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses.Nature communications · 2020Article
- Photoswitching mechanism of a fluorescent protein revealed by time-resolved crystallography and transient absorption spectroscopy.Nature communications · 2020Article
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14 authors.
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Abstract
Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) offers unprecedented possibilities for macromolecular structure determination of systems that are prone to radiation damage. However, phasing XFEL data de novo is complicated by the inherent inaccuracy of SFX data, and only a few successful examples, mostly based on exceedingly strong anomalous or isomorphous difference signals, have been reported. Here, it is shown that SFX data from thaumatin microcrystals can be successfully phased using only the weak anomalous scattering from the endogenous S atoms. Moreover, a step-by-step investigation is presented of the particular problems of SAD phasing of SFX data, analysing data from a derivative with a strong anomalous signal as well as the weak signal from endogenous S atoms.
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