Evidence map›Paper›PMID 27158438›Full record

ReviewMediterranean journal of hematology and infectious diseases2016

The Gut Microbiota and Immune System Relationship in Human Graft-versus-Host Disease.

Lucrezia Laterza, Gianenrico Rizzatti, Eleonora Gaetani, Patrizia Chiusolo, Antonio Gasbarrini

Open access · goldAbstract readReview
In one paragraph

Review in Mediterranean journal of hematology and infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Exploring the role of infectious pathogens in Alzheimer's disease neuroinflammation.Frontiers in cellular and infection microbiology · 2026
    Review
  10. The Role of the Gut Microbiota in Vascular Physiology and Health.International journal of molecular sciences · 2025
    Review
  11. The Role ofToxics · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. The microbiome and acute organ injury: focus on kidneys.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lucrezia LaterzaFondazione Policlinico A. Gemelli, UOC of Internal Medicine, Gastroenterology and Liver Diseases. L.go Gemelli, 8 Rome, Italy.
Gianenrico RizzattiFondazione Policlinico A. Gemelli, UOC of Internal Medicine, Gastroenterology and Liver Diseases. L.go Gemelli, 8 Rome, Italy.
Eleonora GaetaniFondazione Policlinico A. Gemelli, UOC of Internal Medicine, Gastroenterology and Liver Diseases. L.go Gemelli, 8 Rome, Italy.
Patrizia ChiusoloFondazione Policlinico A. Gemelli, Institute of Haematology, L.go Gemelli, 8 Rome, Italy.
Antonio GasbarriniFondazione Policlinico A. Gemelli, UOC of Internal Medicine, Gastroenterology and Liver Diseases. L.go Gemelli, 8 Rome, Italy.
Agostino Gemelli University Polyclinic · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota has gained increasing interest in the pathogenesis of immune-related diseases. In this context, graft-versus-host disease is a condition characterized by an immune response which frequently complicates and limits the outcomes of hematopoietic stem cell transplantations. Past studies, carried mostly in animals, already supported a relationship between gut microbiota and graft-versus-host disease. However, the possible mechanisms underlying this connection remain elusory. Moreover, strategies to prevent graft-versus-host disease are of great interest as well as the potential role of gut microbiota modulation. We reviewed the role of gut microbiota in the development of immune system and its involvement in the graft-versus-host disease, focusing on data available on humans.

Identifiers

PMID27158438
PMCPMC4848019
OpenAlexW2336887990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.