ArticleWorld journal of radiology2016
Quantitative study of prostate cancer using three dimensional fiber tractography.
Article in World journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Diffusion tensor imaging of the pelvic floor muscles and pelvic organs: a systematic review.Frontiers in medical technology · 2026Pooled it
- Diffusion tractography outside the brain: the road less travelled.Brain structure & function · 2026Review
- Mapping the rest of the human connectome: Atlasing the spinal cord and peripheral nervous system.NeuroImage · 2021Review
- Effect of androgen deprivation and radiation therapy on MRI fiber tractography in prostate cancer: can we assess treatment response on imaging?The British journal of radiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate feasibility of a quantitative study of prostate cancer using three dimensional (3D) fiber tractography.
methodsIn this institutional review board approved retrospective study, 24 men with biopsy proven prostate cancer underwent prostate magnetic resonance imaging (MRI) with an endorectal coil on a 1.5 T MRI scanner. Single shot echo-planar diffusion weighted images were acquired with b = 0.600 s/mm(2), six gradient directions. Open-source available software TrackVis and its Diffusion Toolkit were used to generate diffusion tensor imaging (DTI) map and 3D fiber tracts. Multiple 3D spherical regions of interest were drawn over the areas of tumor and healthy prostatic parenchyma to measure tract density, apparent diffusion coefficient (ADC) and fractional anisotropy (FA), which were statistically analyzed.
resultsDTI tractography showed rich fiber tract anatomy with tract heterogeneity. Mean tumor region and normal parenchymal tract densities were 2.53 and 3.37 respectively (P < 0.001). In the tumor, mean ADC was 0.0011 × 10(-3) mm(2)/s vs 0.0014 × 10(-3) mm(2)/s in the normal parenchyma (P < 0.001). The FA values for tumor and normal parenchyma were 0.2047 and 0.2259 respectively (P = 0.3819).
conclusionDTI tractography of the prostate is feasible and depicts congregate fibers within the gland. Tract density may offer new biomarker to distinguish tumor from normal tissue.
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