ArticleAmerican journal of translational research2016
IL-13 induces the expression of 11βHSD2 in IL-13Rα2 dependent manner and promotes the malignancy of colorectal cancer.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Potential Risks Related to Modulating Interleukin-13 and Interleukin-4 Signalling: A Systematic Review.Drug safety · 2018Pooled it
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- Advances in the roles of glycyrrhizic acid in cancer therapy.Frontiers in pharmacology · 2023Review
- Not Only Immune Escape-The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis.Cancers · 2021Review
- Circulating cytokines associated with clinical response to systemic therapy in metastatic renal cell carcinoma.Journal for immunotherapy of cancer · 2021Article
- Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.International journal of molecular sciences · 2021Review
- Resveratrol and its Nanoparticle suppress Doxorubicin/Docetaxel-resistant anaplastic Thyroid Cancer CellsNanotheranostics · 2021Article
- Signal transducer and activator of transcription 6 as a target in colon cancer therapy.Oncology letters · 2020Review
- Type-2 11β-hydroxysteroid dehydrogenase promotes the metastasis of colorectal cancer via the Fgfbp1-AKT pathway.American journal of cancer research · 2020Article
- Using glycyrrhizic acid to target sumoylation processes during Epstein-Barr virus latency.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies had demonstrated that IL-13 and its receptor IL-13Rα2 participated in the process of onset and development of colorectal cancer, however, its detailed mechanism was still unclear. Herein, we demonstrated that IL-13 induced the expression of 11βHSD2 in an IL-13Rα2 dependent manner in colorectal cancer cells. Furthermore, we indicated 11βHSD2 was critical for IL-13 to induce the expression of COX2 and activated Akt, which was essential for IL-13 to promote the colony formation abilities and migration abilities of colorectal cancer cells. Inhibitor of 11βHSD2 glycyrrhizic acid (GA) significantly reduced the liver metastasis of colorectal cancers cells seeded in the Appendix serous of the nude mice. These results provide evidences to reveal the molecular mechanism in the process of colorectal cancer involving IL-13 and its receptor IL-13Rα2, and may provide new therapeutic target for treatment of colorectal cancer.
Indexed as
Identifiers
27158392PMC4846949W2405365450What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.