ArticleAmerican journal of translational research2016
Over-expression of microRNA-223 inhibited the proinflammatory responses in Helicobacter pylori-infection macrophages by down-regulating IRAK-1.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- MicroRNAs as Orchestrators of Immune Responses to Bacterial Infection.Microorganisms · 2026Review
- Article
- Human macrophages release exosomes containing anti-inflammatory microRNAs after phagocytosis ofFrontiers in immunology · 2025Article
- Current research on the interaction between Helicobacter pylori and macrophages.Molecular biology reports · 2024Review
- The regulation roles of miRNAs in Helicobacter pylori infection.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Review
- miR-223: a key regulator of pulmonary inflammation.Frontiers in medicine · 2023Review
- MicroRNA-146a-5p alleviates lipopolysaccharide-induced NLRP3 inflammasome injury and pro-inflammatory cytokine production via the regulation of TRAF6 and IRAK1 in human umbilical vein endothelial cells (HUVECs).Annals of translational medicine · 2021Article
- MicroRNA-490-3p inhibits inflammatory responses in LPS-induced acute lung injury of neonatal rats by suppressing the IRAK1/TRAF6 pathway.Experimental and therapeutic medicine · 2021Article
- MicroRNA Modulation of Host Immune Response and Inflammation Triggered byInternational journal of molecular sciences · 2021Review
- miR-223: An Immune Regulator in Infectious Disorders.Frontiers in immunology · 2021Review
- Platelet Microparticles Enriched in miR-223 Reduce ICAM-1-Dependent Vascular Inflammation in Septic Conditions.Frontiers in physiology · 2021Article
- Overexpression of miR-223 Promotes Tolerogenic Properties of Dendritic Cells Involved in Heart Transplantation Tolerance by Targeting Irak1.Frontiers in immunology · 2021Article
- Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining.American journal of translational research · 2021Review
- Aerobic Exercise Inhibits CUMS-Depressed Mice Hippocampal Inflammatory Response via Activating Hippocampal miR-223/TLR4/MyD88-NF-κB Pathway.International journal of environmental research and public health · 2020Article
- MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis.BMC infectious diseases · 2020Article
- Bta-miR-223 Targeting CBLB Contributes to Resistance toFrontiers in veterinary science · 2020Article
- Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats.Journal of cellular and molecular medicine · 2019Article
- Article
- NF-κB/miR-223-3p/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression.Cell death & disease · 2018Article
- Role of microRNAs and Exosomes inFrontiers in microbiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNA-223 plays an important role in the inflammatory response of macrophages. Recent studies have identified that miR-223 was highly expressed in H. pylori infection macrophages, the significance of the elevation, however, has not yet been investigated. In this study, we analyzed the impact of elevated miR-233 to macrophage inflammatory response and possible mechanisms. We found that miR-223 not only could inhibit the expression of inflammatory cytokines including IL-6, IL-8, IL-12 and TNF-α, but also was able to decrease the expression of CD40, CD68, CD80, and CD163. Furthermore, proteins relating to inflammatory signal pathways, such as IRAK-1, NF-κB and MAPK, in H. pylori infected macrophages were down-regulated. Taken together, these results indicated that miR-223 may act as an inflammatory inhibitory factor in H. pylori infected macrophages by IRAK-1, NF-κB or MAPK signal pathways. These findings contribute to the understanding of miR-223 in macrophages inflammatory responses induced by H. pylori.
Indexed as
Identifiers
27158353PMC4846910W2382542408What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.