ArticleAmerican journal of translational research2016
Mineralocorticoid receptor is involved in the aldosterone pathway in human red blood cells.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Cerebro-Cardiovascular Risk, Target Organ Damage, and Treatment Outcomes in Primary Aldosteronism.Frontiers in cardiovascular medicine · 2021Review
- Primary aldosteronism: Involvement of sympathetic system in the persistence of hypertension after surgery.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Proinflammatory/profibrotic effects of aldosterone in Gitelman's syndrome, a human model opposite to hypertension.Journal of endocrinological investigation · 2019Article
- Licorice: From Pseudohyperaldosteronism to Therapeutic Uses.Frontiers in endocrinology · 2019Review
- Aldosterone in Gynecology and Its Involvement on the Risk of Hypertension in Pregnancy.Frontiers in endocrinology · 2019Review
- Relationship between water and salt intake, osmolality, vasopressin, and aldosterone in the regulation of blood pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Hypothesis on a relationship between hyperaldosteronism, inflammation, somatic mutations, and autoimmunity.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Role of adrenocorticotropic hormone in essential hypertension and primary aldosteronism.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have recently demonstrated that excessive aldosterone (Aldo) secretion in primary aldosteronism (PA) is associated with red blood cells (RBC) senescence. These alterations were prevented/inhibited by cortisol (Cort) or canrenone (Can) raising the hypothesis that Aldo effects in RBC may be mediated by mineralocorticoid receptor (MR), though to date MR has never been demonstrated in human RBC. The aim of this multicenter comparative study was to investigate whether Aldo effects were mediated by MR in these a-nucleated cells. We included 12 healthy controls (HC) and 22 patients with PA. MR presence and activation were evaluated in RBC cytosol by glycerol gradient sedimentation, Western blotting, immuno-precipitation and radioimmunoassay. We demonstrated that RBC contained cytosolic MR, aggregated with HSP90 and other proteins to form multiprotein complex. Aldo induced MR to release from the complex and to form MR dimers which were quickly proteolyzed. Cort induced MR release but not dimers formation while Can was not able to induce MR release. In addition, RBC cytosol from PA patients contained significantly higher amounts of both MR fragments (p<0.0001) and Aldo (p<0.0001) concentrations. In conclusion, in RBC a genomic-like Aldo pathway is proposed involving MR activation, dimerization and proteolysis, but lacking nuclear transcription. In addition, dimers proteolysis may ensure a sort of Aldo scavenging from circulation by entrapping Aldo in MR fragments.
Indexed as
Identifiers
27158328PMC4846885W2404048657What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.