Evidence map›Paper›PMID 27158284›Full record

ArticleCancer and clinical oncology2015

Methylation Markers for Early Detection and Differentiation of Follicular Thyroid Cancer Subtypes.

Josena K Stephen, Kang Mei Chen, Jason Merritt, Dhananjay Chitale, George Divine, Maria J Worsham

Open access · diamondAbstract read
In one paragraph

Article in Cancer and clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. DNA methylation alterations as therapeutic prospects in thyroid cancer.Journal of endocrinological investigation · 2019
    Review
  12. Review
  13. Methylation markers differentiate thyroid cancer from benign nodules.Journal of endocrinological investigation · 2018
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Josena K StephenDepartment of Otolaryngology/Head and Neck Research, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Kang Mei ChenDepartment of Otolaryngology/Head and Neck Research, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Jason MerrittDepartment of Otolaryngology/Head and Neck Research, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Dhananjay ChitaleDepartment of Pathology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
George DivineDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan 48202USA.
Maria J WorshamDepartment of Otolaryngology/Head and Neck Research, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Henry Ford Hospital · US

Funding

DNA methylation markers for early detection of thyroid cancerR03CA159426 · NCI · HENRY FORD HEALTH SYSTEM · PI STEPHEN, JOSENA K · 2012 to 2013
$142k
NCI NIH HHS R03 CA159426
6 · The paper itself

Abstract

Thyroid cancer has the fastest rising incidence rates and is the fifth most common cancer in women. There are four main types of which the papillary and follicular types together account for >90%, followed by medullary cancers (3%-5%) and anaplastic carcinomas (<3%). For individuals who present with early stage disease of papillary and follicular cancers, there are no accurate markers to predict whether they will develop metastatic or recurrent disease. Our immediate goal is to molecularly differentiate follicular cancer subtypes for enhanced classification. Promoter methylation status of genes with reported associations in thyroid cancer (

Indexed as

DNA methylationfollicular thyroid cancerHurthle cell cancerQMSP

Identifiers

PMID27158284
PMCPMC4859763
OpenAlexW1492687050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.