ArticleAnnals of epidemiology2016
The effects of family, dentition, and dental caries on the salivary microbiome.
Article in Annals of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Pooled it
- Meta-Analysis Using NGS Data: TheFrontiers in oral health · 2021Pooled it
- Microbial signatures of dental caries in the incarcerated elderly: a salivary microbiota study in a restricted environment.Journal of oral microbiology · 2026Article
- Kissing as a Protective Factor Against Decreased Salivary pH: Protocol for a Randomized Clinical Trial.JMIR research protocols · 2025Article
- Salivaomics: New Frontiers in Studying the Relationship Between Periodontal Disease and Alzheimer's Disease.Metabolites · 2025Review
- Salivary microbiota profile in adult and children population according to active dentin caries: a metagenomic preliminary analysis.Frontiers in oral health · 2025Article
- The salivary metabolome of children and parental caregivers in a large-scale family environment study.npj metabolic health and disease · 2024Article
- Oral Microbiota-One Habitat or Diverse Niches? A Pilot Study of Sampling and Identification of Oral Bacterial and Fungal Biota in Patients with Type I Diabetes Mellitus Treated with Insulin Pump.International journal of environmental research and public health · 2023Article
- Optimizing the quality of clinical studies on oral microbiome: A practical guide for planning, performing, and reporting.Periodontology 2000 · 2021Review
- Maternal Oral Health Influences Infant Salivary Microbiome.Journal of dental research · 2021Article
- Low levels of salivary metals, oral microbiome composition and dental decay.Scientific reports · 2020Article
- Caries Increment and Salivary Microbiome during University Life: A Prospective Cohort Study.International journal of environmental research and public health · 2020Article
- Impact of polyols on Oral microbiome of Estonian schoolchildren.BMC oral health · 2019Article
- The microbiota of the mother at birth and its influence on the emerging infant oral microbiota from birth to 1 year of age: a cohort study.Journal of oral microbiology · 2019Article
- Associations of the Oral Microbiota with Obesity and Menarche in Inner City Girls.Journal of childhood obesity · 2019Article
- [The Microbiome - The Unscheduled Parameter for Future Therapies].Laryngo- rhino- otologie · 2018Review
- Saliva and tooth biofilm bacterial microbiota in adolescents in a low caries community.Scientific reports · 2017Article
- Article
- Epidemiology and the microbiome.Annals of epidemiology · 2016Article
- A study on genetic and mutans streptococcal transmissibility of dental caries.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
purposeFamily members share genes, environment, and microbial communities. If there is a strong effect of family on the salivary microbiota, controlling for family will enhance identification of microbial communities associated with cariogenesis. The present study was designed to assess the similarity of the salivary microbiome among families and the association between the salivary microbiome and dental decay taking age into account.
methodsWe selected families (n = 49) participating in the cohort study of oral health conducted by the Center for Oral Health Research in Appalachia. All families where at least two children and at least one parent gave a saliva sample (n = 173) were included. Saliva samples were collected at least 1 hour after eating or drinking. After DNA extraction, the V6 region of the 16s rRNA gene was sequenced. Paired ends were joined using fast length adjustment of short reads, sequences were demultiplexed and filtered using Quantitative Insights Into Microbial Ecology 1.9.0, and taxonomy was assigned using the Ribosomal Database Project (RDP; http://rdp.cme.msu.edu/) classifier and sequences aligned with the CORE database using PyNAST.
resultsThe salivary microbiome changed with age and was more similar within families than between families. There was no difference in the diversity of the salivary microbiome by dental decay. After taking into account age and family, signals of dental decay were weak in the saliva, whether examined at the phyla, genus, or operational taxonomic level.
conclusionsThe salivary microbiome does not appear to be a good indicator of dental caries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.