ArticleNature communications2016
Plasticity within non-cerebellar pathways rapidly shapes motor performance in vivo.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Continuous vestibular implant stimulation partially restores eye-stabilizing reflexes.JCI insight · 2019Trial
- Review
- Pulsatile electrical stimulation creates predictable, correctable disruptions in neural firing.Nature communications · 2024Article
- Neuromorphic hardware for somatosensory neuroprostheses.Nature communications · 2024Review
- Article
- Internal models of self-motion: neural computations by the vestibular cerebellum.Trends in neurosciences · 2023Review
- A prosthesis utilizing natural vestibular encoding strategies improves sensorimotor performance in monkeys.PLoS biology · 2022Article
- Difference in Network Effects of Pulsatile and Galvanic Stimulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2022Article
- Simultaneous activation of multiple vestibular pathways upon electrical stimulation of semicircular canal afferents.Journal of neurology · 2020Article
- Predicting Response of Spontaneously Firing Afferents to Prosthetic Pulsatile Stimulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020Article
- Cerebellar Prediction of the Dynamic Sensory Consequences of Gravity.Current biology : CB · 2019Article
- Virtual Rhesus Labyrinth Model Predicts Responses to Electrical Stimulation Delivered by a Vestibular Prosthesis.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Vestibular processing during natural self-motion: implications for perception and action.Nature reviews. Neuroscience · 2019Review
- Enhanced vestibulo-ocular reflex suppression in dancers during passive high-velocity head impulses.Experimental brain research · 2019Article
- Implantable Direct Current Neural Modulation: Theory, Feasibility, and Efficacy.Frontiers in neuroscience · 2019Review
- Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance.Scientific reports · 2017Article
- Characterization of Cochlear, Vestibular and Cochlear-Vestibular Electrically Evoked Compound Action Potentials in Patients with a Vestibulo-Cochlear Implant.Frontiers in neuroscience · 2017Article
- Vestibular implants studied in animal models: clinical and scientific implications.Journal of neurophysiology · 2016Review
- Concurrent VVOR and VORS profiling reveals a threshold-dependent VOR suppression deficit in vestibular migraine.Frontiers in neurologyArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Although cerebellar mechanisms are vital to maintain accuracy during complex movements and to calibrate simple reflexes, recent in vitro studies have called into question the widely held view that synaptic changes within cerebellar pathways exclusively guide alterations in motor performance. Here we investigate the vestibulo-ocular reflex (VOR) circuitry by applying temporally precise activation of vestibular afferents in awake-behaving monkeys to link plasticity at different neural sites with changes in motor performance. Behaviourally relevant activation patterns produce rapid attenuation of direct pathway VOR neurons, but not their nerve input. Changes in the strength of this pathway are sufficient to induce a lasting decrease in the evoked VOR. In addition, indirect brainstem pathways display complementary nearly instantaneous changes, contributing to compensating for the reduced sensitivity of primary VOR neurons. Taken together, our data provide evidence that multiple sites of plasticity within VOR pathways can rapidly shape motor performance in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.