ArticleScientific reports2016
Microfluidic platform combining droplets and magnetic tweezers: application to HER2 expression in cancer diagnosis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Controlled Capture of Magnetic Nanoparticles from Microfluidic Flows by Ferromagnetic Antidot and Dot Nanostructures.Nanomaterials (Basel, Switzerland) · 2025Article
- Microfluidics engineering towards personalized oncology-a review.In vitro models · 2023Review
- Shaking Device for Homogeneous Dispersion of Magnetic Beads in Droplet Microfluidics.Sensors (Basel, Switzerland) · 2023Article
- MicroRNA: An Emerging Predictive, Diagnostic, Prognostic and Therapeutic Strategy in Ischaemic Stroke.Cellular and molecular neurobiology · 2022Review
- Droplet Manipulation under a Magnetic Field: A Review.Biosensors · 2022Review
- Dripping, Jetting and Regime Transition of Droplet Formation in a Buoyancy-Assisted Microfluidic Device.Micromachines · 2020Article
- Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review.Cardiovascular diabetology · 2019Review
- Recent Advances in Droplet-based Microfluidic Technologies for Biochemistry and Molecular Biology.Micromachines · 2019Review
- Continuous magnetic droplets and microfluidics: generation, manipulation, synthesis and detection.Mikrochimica acta · 2019Review
- Review
- High-Throughput Optofluidic Acquisition of Microdroplets in Microfluidic Systems.Micromachines · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of precision medicine, together with the multiplication of targeted therapies and associated molecular biomarkers, call for major progress in genetic analysis methods, allowing increased multiplexing and the implementation of more complex decision trees, without cost increase or loss of robustness. We present a platform combining droplet microfluidics and magnetic tweezers, performing RNA purification, reverse transcription and amplification in a fully automated and programmable way, in droplets of 250nL directly sampled from a microtiter-plate. This platform decreases sample consumption about 100 fold as compared to current robotized platforms and it reduces human manipulations and contamination risk. The platform's performance was first evaluated on cell lines, showing robust operation on RNA quantities corresponding to less than one cell, and then clinically validated with a cohort of 21 breast cancer samples, for the determination of their HER2 expression status, in a blind comparison with an established routine clinical analysis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.