ArticleScientific reports2016
Proteome analysis for the global proteins in the jejunum tissues of enterotoxigenic Escherichia coli -infected piglets.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Dietary anti- Escherichia coli K88 IgY enhances immune response and intestinal barrier function in piglets challenged with Escherichia coli K88.BMC veterinary research · 2026Article
- Kynurenine promotes porcine intestinal epithelial cell proliferation by activating the AHR-MST1-YAP1 axis.Journal of animal science and biotechnology · 2026Article
- Intestinal Alkaline Phosphatase Expression in Response toAnimals : an open access journal from MDPI · 2025Article
- Use of Saliva Analytes as a Predictive Model to Detect Diseases in the Pig: A Pilot Study.Metabolites · 2025Article
- Ningxiang Pig-DerivedAnimals : an open access journal from MDPI · 2024Article
- Integrating Transcriptomics and Proteomics to Characterize the Intestinal Responses to Cadmium Exposure Using a Piglet Model.International journal of molecular sciences · 2024Article
- Effects of EnterotoxigenicMicroorganisms · 2023Article
- Changes in the Saliva Proteome of Pigs with Diarrhoea Caused byProteomes · 2023Article
- Intestinal and Mucosal Microbiome Response to Oral Challenge of EnterotoxigenicPathogens (Basel, Switzerland) · 2022Article
- Tryptophan Ameliorates Barrier Integrity and Alleviates the Inflammatory Response to EnterotoxigenicFrontiers in immunology · 2021Article
- Hierarchical Microbial Functions Prediction by Graph Aggregated Embedding.Frontiers in genetics · 2020Article
- Toll-like receptor 5-mediated IL-17C expression in intestinal epithelial cells enhances epithelial host defense against F4Veterinary research · 2019Article
- Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.Mucosal immunology · 2019Article
- Intestinal microbiota mediates Enterotoxigenic Escherichia coli-induced diarrhea in piglets.BMC veterinary research · 2018Article
- iTRAQ-based quantitative proteomic analysis of embryonic developmental stages in Amur sturgeon, Acipenser schrenckii.Scientific reports · 2018Article
- Jejunal Metabolic Responses toFrontiers in microbiology · 2018Article
- iTRAQ-Based Comparative Proteomic Analysis Reveals Molecular Mechanisms Underlying Wing Dimorphism of the Pea Aphid,Frontiers in physiology · 2018Article
- Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen.Frontiers in immunology · 2018Review
- T Cells in Osteoarthritis: Alterations and Beyond.Frontiers in immunology · 2017Review
- Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during EnterotoxigenicFrontiers in immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterotoxigenic Escherichia coli (ETEC) is a common cause of diarrhea in humans and livestock. In this study, isobaric tags for relative and absolute quantitation (iTRAQ) combined with multidimensional liquid chromatography (LC) and MS analysis was used for screening the differentially expressed proteins in piglet jejunum after ETEC infection. Totally 1,897 proteins were identified with quantitative information in piglet jejunum. We identified 92 differentially expressed proteins in ETEC-induced diarrhea, of which 30 were up regulated and 62 down regulated. Most of the differentially expressed proteins were involved in intestinal function of binding, metabolic process, catalytic activity and immune responses. The inhibition of intestinal immune responses in the jejunum in ETEC-induced diarrhea was also validated by immunobloting and RT-PCR. Our study is the first attempt to analyze the protein profile of ETEC-infected piglets by quantitative proteomics, and our findings could provide valuable information with respect to better understanding the host response to ETEC infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.