Evidence map›Paper›PMID 27157488›Full record

ArticleHearing research2016

Long-term treatment with aldosterone slows the progression of age-related hearing loss.

Joshua Halonen, Ashley S Hinton, Robert D Frisina, Bo Ding, Xiaoxia Zhu, Joseph P Walton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 45 citations in OpenAlex.

  1. Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Adrenal cortex senescence: an ageing-related pathology?Journal of endocrinological investigation · 2025
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  14. Application of New Materials in Auditory Disease Treatment.Frontiers in cellular neuroscience · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Joshua HalonenDepartments of Communication Sciences and Disorders, University of South Florida, Tampa, FL 33620, USA; Global Center of Speech and Hearing Research, University of South Florida, Tampa, FL 33620, USA.
Ashley S HintonDepartments of Communication Sciences and Disorders, University of South Florida, Tampa, FL 33620, USA; Global Center of Speech and Hearing Research, University of South Florida, Tampa, FL 33620, USA.
Robert D FrisinaDepartments of Communication Sciences and Disorders, University of South Florida, Tampa, FL 33620, USA; Chemical and Biomedical Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center of Speech and Hearing Research, University of South Florida, Tampa, FL 33620, USA.
Bo DingDepartments of Communication Sciences and Disorders, University of South Florida, Tampa, FL 33620, USA; Global Center of Speech and Hearing Research, University of South Florida, Tampa, FL 33620, USA.
Xiaoxia ZhuChemical and Biomedical Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center of Speech and Hearing Research, University of South Florida, Tampa, FL 33620, USA.
Joseph P WaltonDepartments of Communication Sciences and Disorders, University of South Florida, Tampa, FL 33620, USA; Chemical and Biomedical Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center of Speech and Hearing Research, University of South Florida, Tampa, FL 33620, USA. Electronic address: jwalton1@usf.edu.
University of South Florida · US

Funding

Structure and Function Services CoreP01AG009524 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI FRISINA, ROBERT D · 1992 to 2021
$23.2M
NIA NIH HHS P01 AG009524
6 · The paper itself

Abstract

Age-related hearing loss (ARHL), clinically referred to as presbycusis, is one of the three most prevalent chronic medical conditions of our elderly, with the majority of persons over the age of 60 suffering from some degree of ARHL. The progressive loss of auditory sensitivity and perceptual capability results in significant declines in workplace productivity, quality of life, cognition and abilities to communicate effectively. Aldosterone is a mineralocorticoid hormone produced in the adrenal glands and plays a role in the maintenance of key ion pumps, including the Na-K(+)-Cl co-transporter 1 or NKCC1, which is involved in homeostatic maintenance of the endocochlear potential. Previously we reported that aldosterone (1 μM) increases NKCC1 protein expression in vitro and that this up-regulation of NKCC1 was not dose-dependent (dosing range from 1 nM to 100 μM). In the current study we measured behavioral and electrophysiological hearing function in middle-aged mice following long-term systemic treatment with aldosterone. We also confirmed that blood pressure remained stable during treatment and that NKCC1 protein expression was upregulated. Pre-pulse inhibition of the acoustic startle response was used as a functional measure of hearing, and the auditory brainstem response was used as an objective measure of peripheral sensitivity. Long-term treatment with aldosterone improved both behavioral and physiological measures of hearing (ABR thresholds). These results are the first to demonstrate a protective effect of aldosterone on age-related hearing loss and pave the way for translational drug development, using aldosterone as a key component to prevent or slow down the progression of ARHL.

Indexed as

AgingAldosteroneAnimalsAuditory ThresholdBlood PressureCognitionDisease ProgressionElectrophysiologyEvoked Potentials, Auditory, Brain StemMiceMice, Inbred CBAPresbycusisQuality of LifeReflex, StartleSolute Carrier Family 12, Member 2Up-RegulationAldosteroneSlc12a2 protein, mouseSolute Carrier Family 12, Member 2AgingAldosteroneDrug developmentHearing lossStartle reflex

Identifiers

PMID27157488
PMCPMC7416673
OpenAlexW2346826992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.